Association between Serum Malondialdehyde Levels and Mortality in Patients with Severe Brain Trauma Injury
| العنوان: | Association between Serum Malondialdehyde Levels and Mortality in Patients with Severe Brain Trauma Injury |
|---|---|
| المؤلفون: | José M. Lorenzo, Ismael Molina, Mónica Argueso, Juan J. Cáceres, María M. Martín, Pedro Abreu-Gonzalez, Alejandro Jiménez, Leonardo Lorente, Jordi Solé-Violán, Luís F. Ramos |
| المصدر: | Journal of Neurotrauma. 32:1-6 |
| بيانات النشر: | Mary Ann Liebert Inc, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Poison control, Gastroenterology, Lipid peroxidation, chemistry.chemical_compound, Injury Severity Score, Malondialdehyde, Intensive care, Internal medicine, medicine, Humans, Glasgow Coma Scale, Prospective Studies, Prospective cohort study, Survival rate, Aged, business.industry, Original Articles, Middle Aged, Prognosis, Survival Analysis, nervous system diseases, Surgery, Survival Rate, Oxidative Stress, nervous system, chemistry, Brain Injuries, Female, Neurology (clinical), business |
| الوصف: | There is a hyperoxidative state in patients with trauma brain injury (TBI). Malondialdehyde (MDA) is an end-product formed during oxidative stress, concretely lipid peroxidation. In small studies (highest sample size 50 patients), higher levels of MDA have been found in nonsurviving than surviving patients with TBI. An association between serum MDA levels and mortality in patients with TBI, however, has not been reported. Thus, the objective of this prospective, observational, multicenter study, performed in six Spanish intensive care units, was to determine whether MDA serum levels are associated with early mortality in a large series of patients with severe TBI. Serum MDA levels were measured in 100 patients with severe TBI on day 1 and in 75 healthy controls. The end-point of the study was 30-day mortality. We found higher serum MDA levels in patients with severe TBI than in healthy controls (p0.001). Nonsurviving patients with TBI (n = 27) showed higher serum MDA levels (p0.001) than survivors (n = 73). Logistic regression analysis showed that serum MDA levels were associated with 30-day mortality (odds ratio [OR] = 4.662; 95% confidence interval [CI] = 1.466-14.824; p = 0.01), controlling for Glasgow Coma Score, age, and computed tomography findings. Survival analysis showed that patients with serum MDA levels higher than 1.96 nmol/mL presented increased 30-day mortality than patients with lower levels (hazard ratio = 3.5; 95% CI = 1.43-8.47; p0.001). Thus, the most relevant new finding of our study, the largest to date on serum MDA levels in patients with severe TBI, was an association between serum MDA levels and early mortality. |
| تدمد: | 1557-9042 0897-7151 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e906f444c16b2f2a7d295e7a8d0aa6aTest https://doi.org/10.1089/neu.2014.3456Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7e906f444c16b2f2a7d295e7a8d0aa6a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15579042 08977151 |
|---|