Mitochondrial Dysfunction and Insulin Resistance in Pubertal Youth Living with Perinatally Acquired HIV
| العنوان: | Mitochondrial Dysfunction and Insulin Resistance in Pubertal Youth Living with Perinatally Acquired HIV |
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| المؤلفون: | Tanvi Sharma, Mariana Gerschenson, Mitchell E. Geffner, Jennifer Jao, Denise L. Jacobson, Jonathan S Russell, Daniel E. Libutti, Russell B. Van Dyke, Greg S. Gojanovich |
| المصدر: | AIDS Res Hum Retroviruses |
| بيانات النشر: | Mary Ann Liebert Inc, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Adolescent, Epidemiology, Immunology, Human immunodeficiency virus (HIV), HIV Infections, Oxidative phosphorylation, Type 2 diabetes, Mitochondrion, medicine.disease_cause, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Virology, Internal medicine, medicine, Humans, 030212 general & internal medicine, Child, business.industry, medicine.disease, Obesity, Mitochondria, 030104 developmental biology, Infectious Diseases, Endocrinology, Leukocytes, Mononuclear, Insulin Resistance, business |
| الوصف: | Mitochondrial dysfunction (MD) is linked to cardiometabolic complications, such as obesity and insulin resistance (IR), the frequencies of which are higher in adults living with HIV infection and receiving combination antiretroviral therapies (ARV). ARV-treated youth living with perinatally acquired HIV infection (YLPHIV) may be especially susceptible to IR due to long-term exposure to both factors. Medical histories, fasting blood chemistry panels, and mitochondrial function in banked peripheral blood mononuclear cells (PBMCs) were assessed in eligible YLPHIV from the Pediatric HIV/AIDS Cohort Study (PHACS)/Adolescent Master Protocol (AMP) Mitochondrial Determinants Component cohort, stratified by Homeostatic Model Assessment of IR (HOMA-IR) score: case (score ≥4, n = 39) or control (score |
| تدمد: | 1931-8405 0889-2229 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c49dbf4f1baa9fe935cebc065fc4bbTest https://doi.org/10.1089/aid.2020.0067Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b4c49dbf4f1baa9fe935cebc065fc4bb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19318405 08892229 |
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