Noninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude
| العنوان: | Noninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude |
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| المؤلفون: | Robert A. Wise, Kaetan J. Vyas, Fabiola León-Velarde, J. Jaime Miranda, David Danz, Robert H. Gilman, William Checkley |
| المصدر: | High Altitude Medicine & Biology. 16:162-168 |
| بيانات النشر: | Mary Ann Liebert Inc, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Scientific Articles, medicine.medical_specialty, purl.org/pe-repo/ocde/ford#3.03.05 [https], Physiology, Point-of-Care Systems, Hematologic Tests/instrumentation/statistics & numerical data, Polycythemia, Altitude Sickness, Hemoglobins/analysis, Sensitivity and Specificity, Altitude Sickness/blood/diagnosis, Hemoglobins, noninvasive methods, Peru, Screening method, Humans, Polycythemia/blood, Medicine, Point-of-Care Systems/statistics & numerical data, excessive erythrocytosis, Oxyhemoglobin saturation, Altitude sickness, chronic mountain sickness, Aged, Hematologic Tests, Hematologic tests, purl.org/pe-repo/ocde/ford#3.01.08 [https], business.industry, Altitude, screening, Public Health, Environmental and Occupational Health, Reproducibility of Results, General Medicine, Venous blood, Middle Aged, Effects of high altitude on humans, medicine.disease, purl.org/pe-repo/ocde/ford#3.03.11 [https], Total hemoglobin, Chronic mountain sickness, Chronic Disease, Emergency medicine, Physical therapy, Female, business |
| الوصف: | Vyas, Kaetan J., David Danz, Robert H. Gilman, Robert A. Wise, Fabiola León-Velarde, J. Jaime Miranda, and William Checkley. Noninvasive assessment of excessive erythrocytosis as a screening method for chronic mountain sickness at high altitude. High Alt Med Biol 16:162–168, 2015.—Globally, over 140 million people are at risk of developing chronic mountain sickness, a common maladaptation to life at high altitude (>2500 meters above sea level). The diagnosis is contingent upon the identification of excessive erythrocytosis (EE). Current best practices to identify EE require a venous blood draw, which is cumbersome for large-scale surveillance. We evaluated two point-of-care biomarkers to screen for EE: noninvasive spot-check tests of total hemoglobin and oxyhemoglobin saturation (Pronto-7, Masimo Corporation). We conducted paired evaluations of total serum hemoglobin from a venous blood draw and noninvasive, spot-check testing of total hemoglobin and oxyhemoglobin saturation with the Pronto-7 in 382 adults aged ≥35 years living in Puno, Peru (3825 meters above sea level). We used the Bland-Altman method to measure agreement between the noninvasive hemoglobin assessment and the gold standard lab hemoglobin analyzer. Mean age was 58.8 years and 47% were male. The Pronto-7 test was unsuccessful in 21 (5%) participants. Limits of agreement between total hemoglobin measured via venous blood draw and the noninvasive, spot-check test ranged from −2.8 g/dL (95% CI −3.0 to −2.5) to 2.5 g/dL (95% CI 2.2 to 2.7), with a bias of −0.2 g/dL (95% CI −0.3 to −0.02) for the difference between total hemoglobin and noninvasive hemoglobin concentrations. Overall, the noninvasive spot-check test of total hemoglobin had a better area under the receiver operating characteristic curve compared to oxyhemoglobin saturation for the identification of EE as measured by a gold standard laboratory hemoglobin analyzer (0.96 vs. 0.82; p |
| تدمد: | 1557-8682 1527-0297 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ba7579dd03aa38525ddbed529f459cTest https://doi.org/10.1089/ham.2015.0026Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....12ba7579dd03aa38525ddbed529f459c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15578682 15270297 |
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