Distribution of the ACE1 D Allele in the Bosnian–Herzegovinian Population and its Possible Role in the Regional Epidemiological Picture of COVID-19
| العنوان: | Distribution of the ACE1 D Allele in the Bosnian–Herzegovinian Population and its Possible Role in the Regional Epidemiological Picture of COVID-19 |
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| المؤلفون: | Larisa Bešić, M Cenanovic, Adna Ašić, Serkan Dogan, Damir Marjanović |
| المصدر: | Genetic Testing and Molecular Biomarkers |
| بيانات النشر: | Mary Ann Liebert Inc, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Genetics, education.field_of_study, medicine.medical_specialty, Incidence (epidemiology), Population, Alu element, General Medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Polymorphism (computer science), 030220 oncology & carcinogenesis, Bayesian multivariate linear regression, Epidemiology, medicine, Genetics(clinical), Allele, education, Allele frequency, Genetics (clinical) |
| الوصف: | Background: The human angiotensin I converting enzyme 1 (ACE1) gene insertion/deletion (I/D) polymorphism is classified based on the presence or absence of a 287 bp Alu sequence. The ACE1 D allele is associated with higher ACE1 concentrations in tissues. Previous research has shown that susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is primarily determined by the affinity between the viral receptor-binding domain and the host human receptor angiotensin-converting enzyme 2 (hACE2) receptor. In the human genome, ACE2 is identified as a homolog to ACE1. Objective: The purpose of this study was to characterize the ACE1 D allele distribution in Bosnia and Herzegovina (B&H), so as to compare it to population data from other European countries and to investigate the potential correlation between D allele frequencies and coronavirus disease 2019 (COVID-19) epidemiological findings in selected European populations. Methods: The ACE1 D allele frequencies in 18 selected European populations were analyzed and compared with COVID-19 prevalence, mortality, and severity using multivariate linear regression analysis. Results and Discussion: The ACE1 D allele distribution within the B&H population was similar to its distribution in other European populations. Regression analysis showed no significant correlation between the D allele frequency and the incidence of infections between the examined populations, nor with the rates of fatality and severe cases. Conclusion: There is no clear statistical evidence that the ACE1 D allele is associated with increased or decreased COVID-19 incidence, mortality, and case severity within the investigated populations. |
| تدمد: | 1945-0257 1945-0265 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9568918570339e191055b20790e41482Test https://doi.org/10.1089/gtmb.2020.0207Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9568918570339e191055b20790e41482 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19450257 19450265 |
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