Gene Transfer Vectors Targeted to Human Prostate Cancer: Do We Need Better Preclinical Testing Systems?
| العنوان: | Gene Transfer Vectors Targeted to Human Prostate Cancer: Do We Need Better Preclinical Testing Systems? |
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| المؤلفون: | Karen F. Chambers, Lindsay J. Georgopoulos, Corrina M.A. de Ridder, Magnus Essand, Angelika Danielsson, Chris H. Bangma, Regina M. Leadley, Helen Evans, Wytske M. van Weerden, Martha Simpson-Holley, Robert Kraaij, Norman J. Maitland |
| المساهمون: | Urology, Internal Medicine |
| المصدر: | Human Gene Therapy, 21(7), 815-827. Mary Ann Liebert Inc. |
| بيانات النشر: | Mary Ann Liebert Inc, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Genetic enhancement, Genetic Vectors, Bioinformatics, Models, Biological, Prostate cancer, SDG 3 - Good Health and Well-being, In vivo, Cell Line, Tumor, Genetics, Animals, Humans, Medicine, Vector (molecular biology), Molecular Biology, Neoplasm Staging, Clinical Trials as Topic, business.industry, Genetic transfer, Prostatic Neoplasms, Cancer, Genetic Therapy, medicine.disease, Clinical trial, Cancer cell, Immunology, Molecular Medicine, business |
| الوصف: | Destruction of cancer cells by genetically modified viral and nonviral vectors has been the aim of many research programs. The ability to target cytotoxic gene therapies to the cells of interest is an essential prerequisite, and the treatment has always had the potential to provide better and more long-lasting therapy than existing chemotherapies. However, the potency of these infectious agents requires effective testing systems, in which hypotheses can be explored both in vitro and in vivo before the establishment of clinical trials in humans. The real prospect of off-target effects should be eliminated in the preclinical stage, if current prejudices against such therapies are to be overcome. In this review we have set out, using adenoviral vectors as a commonly used example, to discuss some of the key parameters required to develop more effective testing, and to critically assess the current cellular models for the development and testing of prostate cancer biotherapy. Only by developing models that more closely mirror human tissues will we be able to translate literature publications into clinical trials and hence into acceptable alternative treatments for the most commonly diagnosed cancer in humans. |
| تدمد: | 1557-7422 1043-0342 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f252c055bfb9094d4a455834ef62aaTest https://doi.org/10.1089/hum.2009.210Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....c4f252c055bfb9094d4a455834ef62aa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577422 10430342 |
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