Cortical Excitability Changes in Patients with Sleep-Wake Disturbances after Traumatic Brain Injury
| العنوان: | Cortical Excitability Changes in Patients with Sleep-Wake Disturbances after Traumatic Brain Injury |
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| المؤلفون: | Stefan Golaszewski, Francesca Caleri, Eugen Trinka, Raffaele Nardone, M. Seidl, F. Gerstenbrand, Frediano Tezzon, Jürgen Bergmann, Alexander Kunz |
| المصدر: | Journal of Neurotrauma. 28:1165-1171 |
| بيانات النشر: | Mary Ann Liebert Inc, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Traumatic brain injury, medicine.medical_treatment, Excessive daytime sleepiness, Poison control, Disorders of Excessive Somnolence, Head trauma, Young Adult, Physical medicine and rehabilitation, medicine, Humans, Wakefulness, Aged, Cerebral Cortex, Epworth Sleepiness Scale, Middle Aged, medicine.disease, Transcranial Magnetic Stimulation, Sleep in non-human animals, Transcranial magnetic stimulation, medicine.anatomical_structure, Cerebral cortex, Brain Injuries, Case-Control Studies, Anesthesia, Female, Neurology (clinical), medicine.symptom, Sleep, Psychology |
| الوصف: | Although chronic sleepiness is common after head trauma, the cause remains unclear. Transcranial magnetic stimulation (TMS) represents a useful complementary approach in the study of sleep pathophysiology. We aimed to determine in this study whether post-traumatic sleep-wake disturbances (SWD) are associated with changes in excitability of the cerebral cortex. TMS was performed 3 months after mild to moderate traumatic brain injury (TBI) in 11 patients with subjective excessive daytime sleepiness (EDS; defined by the Epworth Sleepiness Scale ≥10), 12 patients with objective EDS (as defined by mean sleep latency5 on multiple sleep latency tests), 11 patients with fatigue (defined by daytime tiredness without signs of subjective or objective EDS), 10 patients with post-traumatic hypersomnia "sensu strictu," and 14 control subjects. Measures of cortical excitability included central motor conduction time, resting motor threshold (RMT), short-latency intracortical inhibition (SICI), and intracortical facilitation to paired-TMS. RMT was higher and SICI was more pronounced in the patients with objective EDS than in the control subjects. In the other patients all TMS parameters did not differ significantly from the controls. Similarly to that reported in patients with narcolepsy, the cortical hypoexcitability may reflect the deficiency of the excitatory hypocretin/orexin-neurotransmitter system. These observations may provide new insights into the causes of chronic sleepiness in patients with TBI. A better understanding of the pathophysiology of post-traumatic SWD may also lead to better therapeutic strategies in these patients. |
| تدمد: | 1557-9042 0897-7151 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca93d2d09cd1663bd61cb6244c7fcb5Test https://doi.org/10.1089/neu.2010.1748Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9ca93d2d09cd1663bd61cb6244c7fcb5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15579042 08977151 |
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