Recombinant Human Interleukin-11 Does Not Affect Functions of Purified Human NeutrophilsIn Vitro
| العنوان: | Recombinant Human Interleukin-11 Does Not Affect Functions of Purified Human NeutrophilsIn Vitro |
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| المؤلفون: | Mark S. Klempner, Mark Collins, William L. Trepicchio, Dimitrios Kyvelos, Mary Bozza, Andrew J. Dorner |
| المصدر: | Journal of Interferon & Cytokine Research. 18:889-895 |
| بيانات النشر: | Mary Ann Liebert Inc, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Lipopolysaccharide, Neutrophils, Phagocytosis, medicine.medical_treatment, Immunology, Biology, Pharmacology, chemistry.chemical_compound, Superoxides, Virology, medicine, Humans, Cells, Cultured, Glucuronidase, Innate immune system, L-Lactate Dehydrogenase, Superoxide, Interleukin-8, Chemotaxis, Cell Biology, Interleukin-11, Recombinant Proteins, Interleukin 11, Chemotaxis, Leukocyte, Cytokine, chemistry, Muramidase, Lysozyme |
| الوصف: | Recombinant human interleukin-11 (rHu-IL-11) is a multifunctional cytokine with thrombopoietic activity and demonstrated clinical efficacy in treating chemotherapy-induced thrombocytopenia. rHu-IL-11 also exhibits anti-inflammatory activity and is currently in clinical trials for the treatment of several inflammatory diseases. As neutrophils are involved in both innate immunity and an acute inflammatory response, the effect of rHU-IL-11 on the function of human peripheral blood neutrophils in vitro was examined. rHu-IL-11 was not cytotoxic and did not induce superoxide anion production or the release of granular enzymes from resting neutrophils. Phagocytosis and chemotaxis were unaffected. rHu-IL-11 treatment did not block the response of neutrophils to stimulation. Pretreatment with rHu-IL-11 did not reduce production of IL-8 following activation with lipopolysaccharide (LPS) or zymosan A particles. Pretreatment with rHu-IL-11 did not affect the release of lysozyme and beta-glucuronidase in response to A23187 or PMA-stimulated production of superoxide anion. These results indicate that rHu-IL-11 does not directly modulate key functions of neutrophils in vitro. |
| تدمد: | 1557-7465 1079-9907 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7fe1f0f227be1f1a52fc23ab9b3fa0Test https://doi.org/10.1089/jir.1998.18.889Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3f7fe1f0f227be1f1a52fc23ab9b3fa0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577465 10799907 |
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