Baicalin-Aluminum Modulates the Broiler Gut Microbiome
| العنوان: | Baicalin-Aluminum Modulates the Broiler Gut Microbiome |
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| المؤلفون: | Yinsheng Qiu, Xiaofang Zhang, Dan Zhang, Ling Guo, Yu Liu, Linglu Zhou, Chien-An Andy Hu, Yuzhen Yuan, Shulin Fu, Zhongyuan Wu, Jing He, Chun Ye, Jiacheng Zhang |
| المصدر: | DNA and Cell Biology. 40:881-894 |
| بيانات النشر: | Mary Ann Liebert Inc, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Flavonoids, China, biology, Colistin, Lactobacillus salivarius, Cell Biology, General Medicine, biology.organism_classification, Poultry, Gastrointestinal Microbiome, Microbiology, Metagenomics, Genetics, medicine, Animals, Microbiome, KEGG, Bacteroides fragilis, Chickens, Molecular Biology, Aluminum, Ruminococcaceae, medicine.drug, Bifidobacterium |
| الوصف: | Baicalin-aluminum regulates the gut microbiome of piglets with diarrhea. However, whether it affects poultry gut microbiome composition and function remains unknown. In this study, we used metagenomic sequencing to explore the effects of baicalin-aluminum on gut microbiome changes in poultry when compared with animals administered colistin sulfate. Our data showed that important gut microbiome components consisted of Ruminococcaceae, Subdoligranulum, Bifidobacterium, Bifidobacterium pseudolongum, and Pseudoflavonifractor when broilers were administered baicalin-aluminum compared with colistin. At the species level, Lactobacillus salivarius, Bacteroides uniformis, Oscillibacter unclassified, Bacteroides fragilis, Ruminococcus torques, and Subdoligranulum unclassified abundance were significantly upregulated upon baicalin-aluminum treatment when compared with colistin administration. In addition, Gene Ontology (GO) enrichment analysis indicated that functional differentially expressed genes, which were in the top 30 GO enrichment terms, were associated with metabolic processes, catalytic activity, and cellular processes. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis demonstrated that ABC transporters, oxidative phosphorylation, and phosphotransferase systems were the dominant signaling pathways in the baicalin-aluminum group when compared with the colistin group. Taken together, our data indicated that baicalin-aluminum modified broiler gut microbiome composition. These observations enhance our physiological insights of baicalin-aluminum-mediated functions in the broiler microbiome and potentially provide a novel therapy to manage both animal and human health. |
| تدمد: | 1557-7430 1044-5498 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779a314316648c356b3e29e4739b78b9Test https://doi.org/10.1089/dna.2021.0080Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....779a314316648c356b3e29e4739b78b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577430 10445498 |
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