Thyroglobulin Antibody Is Associated with Increased Cancer Risk in Thyroid Nodules
| العنوان: | Thyroglobulin Antibody Is Associated with Increased Cancer Risk in Thyroid Nodules |
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| المؤلفون: | Eun Sook Kim, Moo Ii Kang, Mee Kyoung Kim, Kwang Woo Lee, Ki Ho Song, Bong Yun Cha, Hyuk-Sang Kwon, Dong Jun Lim, Jongmin Lee, Ki Hyun Baek, Ho Young Son |
| المصدر: | Thyroid. 20:885-891 |
| بيانات النشر: | Mary Ann Liebert Inc, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, Thyroid nodules, endocrine system, Pathology, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Cytological Techniques, Thyroid Gland, Iodide Peroxidase, Thyroglobulin, Antibodies, Autoimmune Diseases, Serology, Autoimmune thyroiditis, Endocrinology, Risk Factors, Thyroid peroxidase, Cytology, medicine, Humans, Thyroid Neoplasms, Thyroid Nodule, Thyroid cancer, Aged, Autoantibodies, biology, business.industry, Histology, Middle Aged, medicine.disease, Anti-thyroid autoantibodies, biology.protein, Female, business |
| الوصف: | The association between autoimmune thyroiditis (AIT) and thyroid cancer is still not clear despite many previous reports. This study investigated whether serologic thyroid antibodies are predictive of thyroid cancer in patients with thyroid nodules.We retrospectively reviewed records of patients with thyroid nodules evaluated by ultrasonography-guided fine-needle aspiration cytology at our institution between January 2006 and December 2008. Thyroid autoimmunity was assessed by measuring thyroglobulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb). The final outcome deciding a benign or malignant status involved a combination of cytology and histology.Of the 1638 patients, malignant nodules had a higher rate of positive TgAb (30.8% vs. 19.6%; p0.001) and elevated thyrotropin (TSH) levels (2.5 +/- 2.8 mIU/L vs. 2.1 +/- 2.0 mIU/L; p = 0.021) than benign nodules. The rate of positive TPOAb was not higher in malignant nodules, although both TPOAb and TgAb were well correlated with TSH levels and histological AIT. In the multivariate analysis, a positive TgAb was significantly associated with thyroid cancer (odds ratio [OR] = 1.61, 95% confidence interval [CI] 1.12-2.33) with upper tertile of normal range of TSH levels (OR = 1.72, 95% CI 1.12-2.63) and above normal range of TSH levels (OR = 1.98, 95% CI 1.06-3.70).We report for the first time that a positive serum TgAb test was an independent predictor for thyroid malignancy in thyroid nodules along with serum TSH levels regardless of the presence of AIT. Our results suggest that TgAb measurement could give additional information for predicting malignancy in cytologically indeterminate thyroid nodules in conjunction with clinical risk factors and TSH levels. |
| تدمد: | 1557-9077 1050-7256 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf5e730ed3f78cacd918ba16fb49273Test https://doi.org/10.1089/thy.2009.0384Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3cf5e730ed3f78cacd918ba16fb49273 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15579077 10507256 |
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