Ibuprofen Enhances Recovery from Spinal Cord Injury by Limiting Tissue Loss and Stimulating Axonal Growth
| العنوان: | Ibuprofen Enhances Recovery from Spinal Cord Injury by Limiting Tissue Loss and Stimulating Axonal Growth |
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| المؤلفون: | Kang-Ho Song, Stephane Budel, Xingxing Wang, Grahame Gould, Stephen M. Strittmatter, Kenneth W. Baughman |
| المصدر: | Journal of Neurotrauma. 26:81-95 |
| بيانات النشر: | Mary Ann Liebert Inc, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, Neurite, medicine.medical_treatment, Growth Cones, Pyramidal Tracts, Ibuprofen, Chick Embryo, Biology, Efferent Pathways, Article, Rats, Sprague-Dawley, Mice, Myelin, Internal medicine, medicine, Animals, Axon, Spinal cord injury, Spinal Cord Injuries, Pyramidal tracts, organic chemicals, Regeneration (biology), Anti-Inflammatory Agents, Non-Steroidal, Axotomy, Spinal cord, medicine.disease, Growth Inhibitors, Nerve Regeneration, Rats, Disease Models, Animal, Endocrinology, medicine.anatomical_structure, Spinal Cord, nervous system, Anesthesia, NIH 3T3 Cells, Raphe Nuclei, Female, Neurology (clinical), rhoA GTP-Binding Protein |
| الوصف: | The GTP-binding protein RhoA regulates microfilament dynamics in many cell types and mediates the inhibition of axonal regeneration by myelin and chondroitin sulfate proteoglycans. Unlike most other nonsteroidal anti-inflammatory drugs, ibuprofen suppresses basal RhoA activity (Zhou et al., 2003). A recent report suggested that ibuprofen promotes corticospinal axon regeneration after spinal cord injury (Fu et al., 2007). Here, we confirm that ibuprofen reduces ligand-induced Rho signaling and myelin-induced inhibition of neurite outgrowth in vitro. Following 4 weeks of subcutaneous administration of ibuprofen, beginning 3 days after spinal cord contusion, animals recovered walking function to a greater degree, with twice as many rats achieving a hind limb weight-bearing status. We examined the relative role of tissue sparing, axonal sprouting, and axonal regeneration in the action of ibuprofen. Histologically, ibuprofen-treated animals display an increase in spared tissue without an alteration in astrocytic or microglial reaction. Ibuprofen increases axonal sprouting from serotonergic raphespinal axons, and from rostral corticospinal fibers in the injured spinal cord, but does not permit caudal corticospinal regeneration after spinal contusion. Treatment of mice with complete spinal cord transection demonstrates long-distance raphespinal axon regeneration in the presence of ibuprofen. Thus, administration of ibuprofen improves the recovery of rats from a clinically relevant spinal cord trauma by protecting tissue, stimulating axonal sprouting, and allowing a minor degree of raphespinal regeneration. |
| تدمد: | 1557-9042 0897-7151 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497346df3d590424b9a0c9e5a709273cTest https://doi.org/10.1089/neu.2007.0464Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....497346df3d590424b9a0c9e5a709273c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15579042 08977151 |
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