Decreasing Disease-Specific Mortality of Differentiated Thyroid Cancer in Korea: A Multicenter Cohort Study
| العنوان: | Decreasing Disease-Specific Mortality of Differentiated Thyroid Cancer in Korea: A Multicenter Cohort Study |
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| المؤلفون: | Tae Yong Kim, Young Kee Shong, Min Ji Jeon, Ho-Cheol Kang, Won Gu Kim, Won Bae Kim, Hee Kyung Kim, Eun Sook Kim, Bo Hyun Kim, Eun Heui Kim, Hyon-Seung Yi |
| المصدر: | Thyroid. 28:1121-1127 |
| بيانات النشر: | Mary Ann Liebert Inc, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, Oncology, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Improved survival, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Adenocarcinoma, Follicular, Republic of Korea, medicine, Humans, In patient, Thyroid Neoplasms, 030212 general & internal medicine, Thyroid cancer, Retrospective Studies, business.industry, Age specific mortality, Age Factors, Middle Aged, Prognosis, medicine.disease, Survival Rate, Thyroid Cancer, Papillary, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Female, sense organs, business, Cohort study |
| الوصف: | Recent studies have reported improved survival in patients with thyroid cancer. This study evaluated the changes in disease-specific survival (DSS) of patients with differentiated thyroid cancer (DTC) in association with clinicopathologic characteristics from 1996 to 2005 in Korea.This was a retrospective, multicenter cohort study. A total of 4398 DTC patients were included, and they were classified according to the year of initial surgery: 1996-2000 (period 1), 2001-2003 (period 2), and 2004-2005 (period 3).During the study period, patient age and the proportion of papillary thyroid cancer increased gradually. Primary tumors became smaller (2.3 ± 1.4 cm at period 1 to 1.5 ± 1.2 cm at period 3; p 0.001). The proportion of high-volume lymph node metastases decreased significantly (20% at period 1 to 13% at period 3; p for trend0.001). DSS differed significantly according to period during the median 10 years follow-up (p = 0.002). The 10-year DSS rates were 98.0%, 98.7%, and 99.2% in periods 1, 2, and 3, respectively. After adjusting for various characteristics, the disease-specific mortality risk was significantly lower during period 2 (hazard ratio = 0.49 [confidence interval CI 0.25-0.90], p = 0.021) and period 3 (hazard ratio = 0.40 [confidence interval 0.21-0.77], p = 0.006) compared to that of period 1. This trend was also significant in a subgroup analysis of low (I-II) and high (III-IV) TNM stages.The disease-specific mortality of patients with DTC in Korea decreased over time. Earlier detection of small DTCs with less extensive disease and standardization of treatment may be associated with this phenomenon. |
| تدمد: | 1557-9077 1050-7256 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558cf8d109cc5b00fd3fb84e4fb981f0Test https://doi.org/10.1089/thy.2018.0159Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....558cf8d109cc5b00fd3fb84e4fb981f0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15579077 10507256 |
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