NLRP3 Inflammasome Is Activated in Fibromyalgia: The Effect of Coenzyme Q10
| العنوان: | NLRP3 Inflammasome Is Activated in Fibromyalgia: The Effect of Coenzyme Q10 |
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| المؤلفون: | Pedro Bullón, Mario D. Cordero, Manuel de Miguel, Elísabet Alcocer-Gómez, José Antonio Sánchez-Alcázar, Maurizio Battino, Eduardo Díaz-Parrado, Eva M. Pérez-Villegas, Ognjen Čulić, Angel M. Carrión |
| المساهمون: | Instituto de Salud Carlos III, European Commission, Junta de Andalucía, Federación Andaluza de Fibromialgia, Síndrome de Fatiga Crónica y Sensibilidad Química Múltiple, Asociación para el Fomento de la Investigación en Cáncer y Mitocondriopatías (España) |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Mary Ann Liebert Inc, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | fibromyalgia, pain, NLRP3, AMPK, Lipopolysaccharides, Male, Fibromyalgia, Inflammasomes, Ubiquinone, Physiology, Interleukin-1beta, Clinical Biochemistry, Gene Expression, Biochemistry, Pyrin domain, Mice, chemistry.chemical_compound, Cells, Cultured, General Environmental Science, Caspase 1, Interleukin, Inflammasome, Algesia, Vitamins, Middle Aged, Mitochondria, Original Research Communications, Hyperalgesia, Cytokines, Female, medicine.symptom, medicine.drug, Adult, Biology, Proinflammatory cytokine, Double-Blind Method, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, Molecular Biology, Coenzyme Q10, Cell Biology, Enzyme Activation, Oxidative Stress, chemistry, Case-Control Studies, Dietary Supplements, Immunology, Leukocytes, Mononuclear, General Earth and Planetary Sciences, Carrier Proteins |
| الوصف: | [Aims]: Fibromyalgia (FM) is a prevalent chronic pain syndrome characterized by generalized hyperalgesia associated with a wide spectrum of symptoms such as fatigue and joint stiffness. Diagnosis of FM is difficult due to the lack of reliable diagnostic biomarkers, while treatment is largely inadequate. We have investigated the role of coenzyme Q10 (CoQ10) deficiency and mitochondrial dysfunction in inflammasome activation in blood cells from FM patients, and in vitro and in vivo CoQ10 deficiency models. [Results]: Mitochondrial dysfunction was accompanied by increased protein expression of interleukin (IL)-1ß, NLRP3 (NOD-like receptor family, pyrin domain containing 3) and caspase-1 activation, and an increase of serum levels of proinflammatory cytokines (IL-1ß and IL-18). CoQ10 deficiency induced by p-aminobenzoate treatment in blood mononuclear cells and mice showed NLRP3 inflammasome activation with marked algesia. A placebo-controlled trial of CoQ10 in FM patients has shown a reduced NLRP3 inflammasome activation and IL-1ß and IL-18 serum levels. [Innovation]: These results show an important role for the NLRP3 inflammasome in the pathogenesis of FM, and the capacity of CoQ10 in the control of inflammasome. Conclusion: These findings provide new insights into the pathogenesis of FM and suggest that NLRP3 inflammasome inhibition represents a new therapeutic intervention for the disease. This work has been supported by the FIS PI10/00543 grant, Fondo Europeo de Desarrollo Regional (FEDER-Unión Europea), SAS 111242 grant, Servicio Andaluz de Salud-Junta de Andalucía, Proyecto de Investigación de Excelencia de la Junta de Andalucía CTS-5725, Federación Andaluza de Fibromialgia y Fatiga Crónica (ALBA Andalucía), and FOICAM (Spanish research association). |
| تدمد: | 1557-7716 1523-0864 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c66fe0062bb55f86c5f8f2a3e9f4501Test https://doi.org/10.1089/ars.2013.5198Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7c66fe0062bb55f86c5f8f2a3e9f4501 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577716 15230864 |
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