Effect on healing rates of wounds treated with direct cold atmospheric plasma: a case series
| العنوان: | Effect on healing rates of wounds treated with direct cold atmospheric plasma: a case series |
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| المؤلفون: | Jennifer Ernst, Andreas Helmke, Moses Ojugo, Wolfgang Viöl, Thomas Borchardt, Arndt F. Schilling, Gunther Felmerer, Murat Tanyeli |
| المصدر: | Journal of Wound Care. 30:904-914 |
| بيانات النشر: | Mark Allen Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Wound Healing, Nursing (miscellaneous), Plasma Gases, integumentary system, business.industry, Research, Atmospheric-pressure plasma, 01 natural sciences, 010305 fluids & plasmas, 3. Good health, Microcirculation, 030207 dermatology & venereal diseases, 03 medical and health sciences, Wound care, 0302 clinical medicine, Child, Preschool, Anesthesia, 0103 physical sciences, Humans, Medicine, Tissue hypoxia, Fundamentals and skills, Plasma medicine, Wound healing, business |
| الوصف: | Objective: The response of different critical acute and hard-to-heal wounds to an innovative wound care modality—direct application of cold atmospheric plasma (CAP)—was investigated in this clinical case series. Method: Over an observation period of two years, acute wounds with at least one risk factor for chronification, as well as hard-to-heal wounds were treated for 180 seconds three times per week with CAP. CAP treatment was additional to standard wound care. Photographs were taken for wound documentation. The wound sizes before the first CAP treatment, after four weeks, after 12 weeks and at wound closure/end of observation time were determined using image processing software, and analysed longitudinally for the development of wound size. Results: A total of 27 wounds (19 hard-to-heal and eight acute wounds) with a mean wound area of 15cm2 and a mean wound age of 49 months were treated with CAP and analysed. All (100%) of the acute wounds and 68% of the hard-to-heal wounds healed after an average treatment duration of 14.2 weeks. At the end of the observation period, 21% of hard-to-heal wounds were not yet closed but were reduced in size by >80%. In 11% of the hard-to-heal wounds (n=2) therapy failed. Conclusion: The results suggested a beneficial effect of additional CAP therapy on wound healing. Declaration of interest: This work was carried out within the research projects ‘Plasma for Life’ (funding reference no. 13FH6I04IA) with financial support from the German Federal Ministry of Education and Research (BMBF). In the past seven years AFS has provided consulting services to Evonik and has received institutional support by Heraeus, Johnson & Johnson and Evonik. There are no royalties to disclose. The Department for Trauma Surgery, Orthopaedics and Plastic Surgery received charitable donations by CINOGY GmbH. CINOGY GmbH released the di_CAP devices and electrodes for the study. WV and AH were involved in the development of the used di_CAP device (Plasmaderm, CINOGY GmbH). WV is shareholder of the outsourced start-up company CINOGY GmbH. |
| تدمد: | 2052-2916 0969-0700 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee018a93189d465d2d753b9cbfb730bTest https://doi.org/10.12968/jowc.2021.30.11.904Test |
| رقم الانضمام: | edsair.doi.dedup.....8ee018a93189d465d2d753b9cbfb730b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20522916 09690700 |
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