Association of rs7903146 polymorphism in the TCF7L2 gene with diabetic nephropathy and decreased estimated GFR in an Arab population in southwest Iran
| العنوان: | Association of rs7903146 polymorphism in the TCF7L2 gene with diabetic nephropathy and decreased estimated GFR in an Arab population in southwest Iran |
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| المؤلفون: | Ali Karimi Akhormeh, Mehrnoosh Zakerkish, Mohammad Taha Jalali, Narges Mohammadtaghvaei, Hamid Yaghooti, Ramin Tavakoli |
| المصدر: | Journal of Nephropathology. 7:273-280 |
| بيانات النشر: | Maad Rayan Publishing Company, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Creatinine, medicine.medical_specialty, biology, business.industry, Renal function, Odds ratio, medicine.disease, Diabetic nephropathy, chemistry.chemical_compound, Endocrinology, chemistry, Cystatin C, Nephrology, Internal medicine, Diabetes mellitus, Genotype, medicine, biology.protein, business, TCF7L2 |
| الوصف: | Background: Transcription factor 7-like 2 (TCF7L2) acts as a downstream effector in the Wnt signaling pathway. It plays important roles in the proliferation and differentiation of islet betacell, insulin secretion and kidney development. Objectives: This study aimed to demonstrate whether rs7903146 variant is associated with diabetic nephropathy (DN) and measures of kidney function in a diabetic and healthy Arab population in southwest of Iran. Patients and Methods: This study is comprised of 132 diabetic subjects (T2DM) and 66 healthy participants. The diabetic subgroups were composed of patients with DN (n=56) and early onset of diabetes (n=71). The rs7903146 polymorphism was genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in all the participants. Blood glucose, HbA1c, blood urea nitrogen (BUN), creatinine and urinary albumin were evaluated by a biochemistry analyzer and enzyme-linked immunosorbent assay (ELISA) was employed for cystatin C measurement. Results: The frequency of genotypes was significantly different between all the diabetic cases and control subjects (P |
| تدمد: | 2251-8819 2251-8363 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::4d6ed2130a614d7a90351d5cd7159210Test https://doi.org/10.15171/jnp.2018.54Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........4d6ed2130a614d7a90351d5cd7159210 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22518819 22518363 |
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