دورية أكاديمية
Risk stratification after recurrence of human papillomavirus (HPV)-related and non-HPV-related oropharyngeal cancer: Secondary analysis of NRG Oncology RTOG 0129 and 0522.
| العنوان: | Risk stratification after recurrence of human papillomavirus (HPV)-related and non-HPV-related oropharyngeal cancer: Secondary analysis of NRG Oncology RTOG 0129 and 0522. |
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| المؤلفون: | Bigelow, Elaine O, Harris, Jonathan, Fakhry, Carole, Gillison, Maura L, Nguyen-Tân, Phuc Felix, Rosenthal, David I, Frank, Steven J, Nair, Suresh G., MD, Bahig, Houda, Ridge, John A, Caudell, Jimmy, Donaldson, Craig, Clifford, Bradley T, Shenouda, George, Birrer, Michael J, Chen, Yuhchyau, Le, Quynh-Thu |
| المصدر: | Hematology-Medical Oncology Division |
| بيانات النشر: | LVHN Scholarly Works |
| سنة النشر: | 2022 |
| المجموعة: | Lehigh Valley Health Network: LVHN Scholarly Works |
| مصطلحات موضوعية: | Alphapapillomavirus, Humans, Neoplasm Recurrence, Local, Oropharyngeal Neoplasms, Papillomaviridae, Papillomavirus Infections, Prospective Studies, Retrospective Studies, Risk Assessment, Department of Medicine, Hematology-Medical Oncology Division, Medicine and Health Sciences |
| الوصف: | BACKGROUND: No risk-stratification strategies exist for patients with recurrent oropharyngeal cancer (OPC). METHODS: Retrospective analysis using data from prospective NRG Oncology clinical trials RTOG 0129 and 0522. Eligibility criteria included known p16 status and smoking history, and locoregional/distant recurrence. Overall survival (OS) was measured from date of recurrence. Recursive partitioning analysis was performed to produce mutually exclusive risk groups. RESULTS: Hundred and fifty-four patients were included with median follow-up after recurrence of 3.9 years (range 0.04-9.0). The most important factors influencing survival were p16 status and type of recurrence, followed by surgical salvage and smoking history (≤20 vs. >20 pack-years). Three significantly different risk groups were identified. Patients in the low-, intermediate-, and high-risk groups had 2-year OS after recurrence of 81.1% (95%CI 68.5-93.7), 50.2% (95%CI 36.0-64.5), and 20.8% (95%CI 10.5-31.1), respectively. CONCLUSION: Patient and tumor characteristics may be used to stratify patients into risk groups at the time of OPC recurrence. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://scholarlyworks.lvhn.org/hematology-medical-oncology-division/22Test; https://pubmed.ncbi.nlm.nih.gov/34729846Test/ |
| الإتاحة: | https://scholarlyworks.lvhn.org/hematology-medical-oncology-division/22Test https://pubmed.ncbi.nlm.nih.gov/34729846Test/ |
| رقم الانضمام: | edsbas.1CA38410 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |