Risk Related to Pre-Diabetes Mellitus and Diabetes Mellitus in Heart Failure with Reduced Ejection Fraction: Insights from Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial
التفاصيل البيبلوغرافية
العنوان:
Risk Related to Pre-Diabetes Mellitus and Diabetes Mellitus in Heart Failure with Reduced Ejection Fraction: Insights from Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial
Kristensen, S L, Preiss, D, Jhund, P S, Squire, I, Cardoso, J S, Merkely, B, Martinez, F, Starling, R C, Desai, A S, Lefkowitz, M P, Rizkala, A R, Rouleau, J L, Shi, V C, Solomon, S D, Swedberg, K, Zile, M R, McMurray, J J V, Packer, M & PARADIGM-HF Investigators and Committees 2016, ' Risk Related to Pre-Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction : Insights From Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial ', Circulation. Heart Failure, vol. 9, no. 1 . https://doi.org/10.1161/CIRCHEARTFAILURE.115.002560Test Circulation. Heart Failure Circulation. Heart failure, 9(1). United States (2016).
Background— The prevalence of pre–diabetes mellitus and its consequences in patients with heart failure and reduced ejection fraction are not known. We investigated these in the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial. Methods and Results— We examined clinical outcomes in 8399 patients with heart failure and reduced ejection fraction according to history of diabetes mellitus and glycemic status (baseline hemoglobin A1c [HbA1c]: P 6.5%) and known diabetes mellitus compared with those with HbA1cP P P Conclusions— In patients with heart failure and reduced ejection fraction, dysglycemia is common and pre–diabetes mellitus is associated with a higher risk of adverse cardiovascular outcomes (compared with patients with no diabetes mellitus and HbA1c Clinical Trial Registration— URL: http://www.clinicaltrials.govTest . Unique identifier: NCT01035255.
