Comparative study of the efficacy of olmesartan/amlodipine vs. perindopril/amlodipine in peripheral blood pressure after missed dose in type 2 diabetes
| العنوان: | Comparative study of the efficacy of olmesartan/amlodipine vs. perindopril/amlodipine in peripheral blood pressure after missed dose in type 2 diabetes |
|---|---|
| المؤلفون: | Redon, Josep, Pichler, Gernot, Missed Dose Study Group: Redon, J, Pascual, Jm, Olivan Martinez, J, Martell, N, Calvo Gomez, C, Lembo, G, Benedetto, Fa, De Curtis, G, Desideri, G, Dognini, Gp, Ferri, C, Fogari, R, Ganau, A, Gargiulo, A, Gaudio, G, Germanò, G, Malatino, L, Bucci, M, Mos, L, Novo, S, Pedrinelli, Roberto, Perticone, F, Portaluppi, F, Mulé, G, Sarzani, R, Schillaci, G, Spagnuolo, V, Strazzullo, P, Taddei, S, Trimarco, B, Veglio, F, Verdecchia, P, Volpe, M, Tsioufis, C, Zakopoulos, N, Zamboulis, C, Schmieder, Re, Bönner, G, Sehnert, W, Haller, H, Scholze, J, Burnier, M, Hayoz, D, Asmar, R, Blacher, J, Benetos, A, Gosse, P, Mounier Vehier, C, Thuillez, C. |
| المساهمون: | Redon, J, Pichler, G, Mule, G, Redon, Josep, Pichler, Gernot, Strazzullo, Pasquale |
| المصدر: | JOURNAL OF HYPERTENSION r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname |
| بيانات النشر: | Lippincott Williams and Wilkins, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Settore MED/09 - Medicina Interna, Antihypertensive agents, Physiology, Missed Dose, Tetrazoles, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, 030204 cardiovascular system & hematology, Pharmacology, Essential hypertension, law.invention, 0302 clinical medicine, Diabetes mellitus, Randomized controlled trial, law, Angiotensin II Type 1 Receptor Blocker, Drug Combination, Perindopril, Medicine, 030212 general & internal medicine, Antihypertensive agent, Tetrazole, Imidazoles, Settore MED/37 - Neuroradiologia, Middle Aged, Calcium Channel Blockers, Drug Combinations, Treatment Outcome, Hypertension, Female, Essential Hypertension, Olmesartan, Calcium Channel Blocker, Cardiology and Cardiovascular Medicine, Type 2, circulatory and respiratory physiology, medicine.drug, Human, Adult, medicine.medical_specialty, Amlodipine, Blood pressure, Internal Medicine, Diabetes mellitu, missed dose, hypertension, therapeutic efficacy, Combination therapy, Urology, NO, Medication Adherence, 03 medical and health sciences, Double-Blind Method, Humans, amlodipine, antihypertensive agents, blood pressure, diabetes mellitus, olmesartan, perindopril, Imidazole, Aged, business.industry, Angiotensin-Converting Enzyme Inhibitor, medicine.disease, Angiotensin II Type 1 Receptor Blockers, Antihypertensive Agents, Diabetes Mellitus, Type 2, business |
| الوصف: | Introduction: Combination therapy is needed to control blood pressure (BP) in a large number of hypertensive patients with diabetes mellitus. Adherence to treatment is a major clinical problem; therefore, the time duration of the antihypertensive action of a drug determines BP control when a dose is skipped. Objectives: The aim was to determine whether the fixed-dose combination of olmesartan/amlodipine provides equal efficacy and safety as the perindopril/amlodipine combination when a drug dose is missed. Methods: In this noninferiority trial with a randomized, double-blind, double-dummy parallel group, controlled design, 260 patients received either olmesartan 20-40 mg/amlodipine 5-10 mg or perindopril 4-8 mg/amlodipine 5-10 mg for 24 weeks. The main outcome was the sitting office DBP after 24 weeks of treatment at 48 h from last administration. Results: The olmesartan/amlodipine combination reached noninferiority criteria in reduction of office DBP after 24 weeks of treatment and after the missed dose, compared with the perindopril/amlodipine combination (-11.7 and -10.5 mmHg, respectively). Office SBP and pulse pressure were significantly lower in both groups after 24 weeks of treatment and 48 h after the missed dose, observing a trend to greater SBP reduction in the olmesartan/amlodipine group. Conclusions: The combination olmesartan/amlodipine is safe, well tolerated, and as effective as the combination of perindopril/amlodipine in the control of essential hypertension in patients with diabetes mellitus. A missed dose does not leave the patients unprotected in both treatments; however, a faster control with less dose increment is observed with olmesartan/amlodipine. |
| اللغة: | English |
| تدمد: | 0263-6352 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d51c0f5d113a0a36025d8153fef258Test http://hdl.handle.net/10447/211213Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c9d51c0f5d113a0a36025d8153fef258 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02636352 |
|---|