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Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo

التفاصيل البيبلوغرافية
العنوان: Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo
المؤلفون: De Lizarrondo S.M., Roncal C., Calvayrac O., Rodríguez C., Varo N., Purroy A., Lorente L., Rodríguez J.A., Doeuvre L., Hervás-Stubbs S., Angles-Cano E., Páramo J.A., Martínez-González J., Orbe J.
المصدر: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
بيانات النشر: LIPPINCOTT WILLIAMS & WILKINS, 2012.
سنة النشر: 2012
مصطلحات موضوعية: mitogen activated protein kinase p38, Lipopolysaccharides, Male, Mice, Antigens, CD40, Cell-Derived Microparticles, stress activated protein kinase 1, endothelium cell, Cells, Cultured, Aged, 80 and over, Mice, Knockout, messenger RNA, lipopolysaccharide, proteinase activated receptor 1, article, Hirudins, Middle Aged, thrombin, priority journal, Female, CD40 ligand, Adult, in vitro study, animal experiment, Antibodies, Gene Expression Regulation, Enzymologic, in vivo study, Matrix Metalloproteinase 10, Human Umbilical Vein Endothelial Cells, hirudin, Animals, Humans, controlled study, Mitogen-Activated Protein Kinase 8, human, protein expression, Blood Coagulation, mouse, thrombosis, endothelial microparticle, Aged, nonhuman, animal model, human cell, Endothelial Cells, Disseminated Intravascular Coagulation, major clinical study, human tissue, Endotoxemia, p38 Mi, Mice, Inbred C57BL, Disease Models, Animal, Case-Control Studies, Multivariate Analysis, stromelysin 2
الوصف: Objective-Thrombin induces CD40 ligand (CD40L) and matrix metalloproteinases (MMPs) under inflammatory/prothrombotic conditions. Thrombin and CD40L could modulate endothelial MMP-10 expression in vitro and in vivo. Methods and Results-Human endothelial cells were stimulated with thrombin (0.1-10 U/mL), CD40L (0.25-1 µg/mL), or their combination (thrombin/CD40L) to assess MMP-10 expression and microparticle generation. Thrombin/CD40L elicited higher MMP-10 mRNA (5-fold; P
تدمد: 1079-5642
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::7f45a90978813580b62bcfba5af24c36Test
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84861529113&doi=10.1161/ATVBAHA.112.248773&partnerID=40&md5=b2c680a78119daa02281671ac1b2415dTest
حقوق: OPEN
رقم الانضمام: edsair.RECOLECTA.....7f45a90978813580b62bcfba5af24c36
قاعدة البيانات: OpenAIRE
الوصف
تدمد:10795642