Coronavirus disease 2019 in patients with inborn errors of immunity: lessons learned
| العنوان: | Coronavirus disease 2019 in patients with inborn errors of immunity: lessons learned |
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| المؤلفون: | Isabelle Meyts, Giorgia Bucciol, Stuart G. Tangye |
| المصدر: | Current Opinion in Pediatrics |
| بيانات النشر: | Lippincott Williams & Wilkins, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, inborn errors of immunity, Primary Immunodeficiency Diseases, Population, medicine.disease_cause, primary immunodeficiency, Combined immunodeficiencies, coronavirus disease 2019, Immunity, Case fatality rate, Pandemic, medicine, Humans, Risk factor, education, education.field_of_study, Innate immune system, business.industry, SARS-CoV-2, COVID-19, Immune dysregulation, medicine.disease, Pediatrics, Perinatology and Child Health, Disease Progression, ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange, Disease Susceptibility, business, severe acute respiratory syndrome coronavirus 2 |
| الوصف: | Purpose of review The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused extreme concern for patients with inborn errors of immunity (IEIs). In the first 6 months of the pandemic, the case fatality rate among patients with IEIs resembled that of the general population (9%). This review aims at summarizing what we have learned about the course and outcome of coronavirus disease 2019 (COVID-19) in patients with different IEIs and what this can potentially teach us about the immune mechanisms that could confer protection or predisposition to severe disease. Recent findings A total of 649 patients with IEI and COVID-19 have been reported in the last year and a half, spanning all groups of the International Union of Immunological Societies classification of IEIs. For most patients, the underlying IEI does not represent an independent risk factor for severe COVID-19. In fact, some IEI may even be protective against the severe disease due to impaired inflammation resulting in less immune-mediated collateral tissue damage. Summary We review the characteristics of SARS-CoV-2 infection in a large number of patients with IEI. Overall, we found that combined immunodeficiencies, immune dysregulation disorders, and innate immune defects impairing type I interferon responses are associated with severe disease course. |
| اللغة: | English |
| تدمد: | 1531-698X 1040-8703 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ec018a7debd48402085dd9c7f98529Test http://europepmc.org/articles/PMC8577305Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....52ec018a7debd48402085dd9c7f98529 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1531698X 10408703 |
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