Spontaneous Ventricular Fibrillation in Right Ventricular Failure Secondary to Chronic Pulmonary Hypertension
| العنوان: | Spontaneous Ventricular Fibrillation in Right Ventricular Failure Secondary to Chronic Pulmonary Hypertension |
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| المؤلفون: | Rajeev Saggar, Aneesh Bapat, Rajan Saggar, Mansoureh Eghbali, Soban Umar, Jong-Hwan Lee, Rod Partow-Navid, Arnoud van der Laarse, Dirk L. Ypey, Andrea Iorga, Enno de Lange, Hrayr S. Karagueuzian |
| المساهمون: | DKE Scientific staff, RS: FSE DACS |
| المصدر: | Circulation-Arrhythmia and Electrophysiology, 5, 181-190. LIPPINCOTT WILLIAMS & WILKINS Circulation: Arrhythmia and Electrophysiology, 5(1), 181-U305 |
| بيانات النشر: | LIPPINCOTT WILLIAMS & WILKINS, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Hypertension, Pulmonary, Ventricular Dysfunction, Right, Hemodynamics, Sudden death, Article, Afterdepolarization, Rats, Sprague-Dawley, Electrocardiography, Heart Rate, Physiology (medical), Internal medicine, pulmonary hypertension, medicine, Animals, Heart Failure, Ejection fraction, medicine.diagnostic_test, business.industry, right ventricular failure, Prognosis, ventricular fibrillation, medicine.disease, Pulmonary hypertension, Rats, Disease Models, Animal, optical mapping, early afterdepolarization, Anesthesia, Heart failure, Ventricular fibrillation, Disease Progression, Cardiology, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies |
| الوصف: | Background— Right ventricular failure (RVF) in pulmonary hypertension (PH) is associated with increased incidence of sudden death by a poorly explored mechanism. We test the hypothesis that PH promotes spontaneous ventricular fibrillation (VF) during a critical post-PH onset period characterized by a sudden increase in mortality. Methods and Results— Rats received either a single subcutaneous dose of monocrotaline (MCT, 60 mg/kg) to induce PH-associated RVF (PH, n=24) or saline (control, n=17). Activation pattern of the RV-epicardial surface was mapped using voltage-sensitive dye in isolated Langendorff-perfused hearts along with single glass-microelectrode and ECG-recordings. MCT-injected rats developed severe PH by day 21 and progressed to RVF by approximately day 30. Rats manifested increased mortality, and ≈30% rats died suddenly and precipitously during 23–32 days after MCT. This fatal period was associated with the initiation of spontaneous VF by a focal mechanism in the RV, which was subsequently maintained by both focal and incomplete reentrant wave fronts. Microelectrode recordings from the RV-epicardium at the onset of focal activity showed early afterdepolarization–mediated triggered activity that led to VF. The onset of the RV cellular triggered beats preceded left ventricular depolarizations by 23±8 ms. The RV but not the left ventricular cardiomyocytes isolated during this fatal period manifested significant action potential duration prolongation, dispersion, and an increased susceptibility to depolarization-induced repetitive activity. No spontaneous VF was observed in any of the control hearts. RVF was associated with significantly reduced RV ejection fraction ( P P P Conclusions— PH-induced RVF is associated with a distinct phase of increased mortality characterized by spontaneous VF arising from the RV by an early afterdepolarization–mediated triggered activity. |
| اللغة: | English |
| تدمد: | 1941-3084 1941-3149 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a3a618be2e263cf9d67195bee3305fTest https://cris.maastrichtuniversity.nl/en/publications/8631ba14-3b1a-4bb7-9897-b51964170df4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c0a3a618be2e263cf9d67195bee3305f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19413084 19413149 |
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