دورية أكاديمية
Altered calcium and sodium metabolism in red blood cells of hypertensive man: assessment by ion-selective electrodes.
| العنوان: | Altered calcium and sodium metabolism in red blood cells of hypertensive man: assessment by ion-selective electrodes. |
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| المؤلفون: | Wehling, M., Vetter, W., Neyses, Ludwig, Groth, H., Boerlin, H. J., Locher, R., Siegenthaler, W., Kuhlmann, U. |
| المصدر: | Journal of Hypertension, 1 (2), 171-6 (1983) |
| بيانات النشر: | Lippincott Williams & Wilkins |
| سنة النشر: | 1983 |
| المجموعة: | University of Luxembourg: ORBilu - Open Repository and Bibliography |
| مصطلحات موضوعية: | Adenosine Triphosphate/blood, Adult, Aged, Calcium/blood, Electrodes, Erythrocytes/metabolism, Female, Hemolysis, Humans, Hypertension/blood, Male, Middle Aged, Potassium/blood, Sodium/blood, Human health sciences, Cardiovascular & respiratory systems, Sciences de la santé humaine, Systèmes cardiovasculaire & respiratoire |
| الوصف: | peer reviewed ; Free intracellular calcium [Ca2+]i, sodium [Na+]i and potassium [K+]i were assessed in freeze-thawed human red blood cells (RBC) by ion-selective electrodes. After metabolic depletion by 30 mM 2-desoxy-glucose, [Ca2+]i increased faster and to significantly higher values in RBC from 16 patients with mild to moderate essential hypertension (mean diastolic blood pressure 111 +/- 10 mmHg) than in the RBC of 24 normotensives. The rate of [Ca2+]i increase was 7.0 +/- 3.6 versus 3.7 +/- 4.0 mumol/h/l cells (P less than 0.01) for the first 24 h and 8.1 +/- 4.8 versus 6.4 +/- 3.5 mumol/h/l cells for the following 24 h. [Na+]i before and after 24 h incubation was significantly higher in hypertensives, whereas basal [Ca2+]i and [K+]i before and after incubation were the same in both groups. After Ca loading by ionophore A 23187, the maximum rate of [Ca2+]i extrusion was not significantly lower in intact RBC from hypertensives than in those from normotensives (59.5 +/- 7.8 versus 87.9 +/- 18.1 mumol/min/l cells). These results indicate disturbances in RBC Ca metabolism similar to those observed earlier for Na and K. If generalized, the defect could lead to raised [Ca2+]i in smooth muscle and sympathetic nerve tissue, thus causing increased vascular tone and probably catecholamine release with subsequent arterial hypertension. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0263-6352 |
| العلاقة: | http://ovidsp.tx.ovid.com/sp-3.13.0b/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&AN=00004872-198308000-00010&NEWS=N&CSC=Y&CHANNEL=PubMedTest; urn:issn:0263-6352; https://orbilu.uni.lu/handle/10993/27464Test; info:hdl:10993/27464; scopus-id:2-s2.0-0021013305; info:pmid:6681037 |
| DOI: | 10.1097/00004872-198308000-00010 |
| الإتاحة: | https://doi.org/10.1097/00004872-198308000-00010Test https://orbilu.uni.lu/handle/10993/27464Test |
| رقم الانضمام: | edsbas.E06AC6CF |
| قاعدة البيانات: | BASE |
| تدمد: | 02636352 |
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| DOI: | 10.1097/00004872-198308000-00010 |