دورية أكاديمية
Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies.
| العنوان: | Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies. |
|---|---|
| المؤلفون: | O'Keefe, James H, Tintle, Nathan L, Venø, Stine Krogh, Chien, Kuo-Liong, Chen, Yun-Yu Amelia, Egert, Sarah, Feldreich, Tobias Rudholm, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G, Geleijnse, Johanna M, Pertiwi, Kamalita, Harris, William S, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, O'Keefe, Evan L, Laguzzi, Federica, Swenson, Brenton R, Longstreth, William T, Manson, JoAnn E, Mora, Samia, Cook, Nancy R, Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Sala-Vila, Aleix, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V, Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Attia, John, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M Kamran, Tanaka, Toshiko, Das, Jayanta K, Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, G Manohar, Garg, Parveen, Verschuren, W M Monique, Boer, Jolanda M A, Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S, Hure, Alexis, Lemaitre, Rozenn N, Mozaffarian, Dariush, Bork, Christian Sørensen, Schmidt, Erik Berg |
| المصدر: | Stroke 55(1), 50 - 58 (2024). doi:10.1161/STROKEAHA.123.044281 |
| بيانات النشر: | Lippincott Williams & Wilkins |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/610, Humans, Prospective Studies, Eicosapentaenoic Acid, Docosahexaenoic Acids, Hemorrhagic Stroke: epidemiology, Fatty Acids, Omega-3, Stroke: epidemiology, Ischemic Stroke, Risk Factors, atrial fibrillation, cerebrovascular disease, fish, fish oil, stroke |
| جغرافية الموضوع: | DE |
| الوصف: | The effect of marine omega-3 PUFAs on risk of stroke remains unclear.We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome.Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76-0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74-0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81-0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78-0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD.Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/pmid:38134264; info:eu-repo/semantics/altIdentifier/issn/1524-4628; info:eu-repo/semantics/altIdentifier/issn/0039-2499; https://pub.dzne.de/record/266761Test; https://pub.dzne.de/search?p=id:%22DZNE-2024-00024%22Test |
| الإتاحة: | https://doi.org/10.1161/STROKEAHA.123.044281Test https://pub.dzne.de/record/266761Test https://pub.dzne.de/search?p=id:%22DZNE-2024-00024%22Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.26D5035 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |