التفاصيل البيبلوغرافية
| العنوان: |
Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns Findings From the Pregnancy and Childhood Epigenetics Consortium |
| المؤلفون: |
Kazmi, Nabila, Sharp, Gemma C., Reese, Sarah E., Vehmeijer, Florianne O., Lahti, Jari, Page, Christian M., Zhang, Weiming, Rifas-Shiman, Sheryl L., Rezwan, Faisal I., Simpkin, Andrew J., Burrows, Kimberley, Richardson, Tom G., Ferreira, Diana L. Santos, Fraser, Abigail, Harmon, Quaker E., Zhao, Shanshan, Jaddoe, Vincent W. V., Czamara, Darina, Binder, Elisabeth B., Magnus, Maria C., Haberg, Siri E., Nystad, Wenche, Nohr, Ellen A., Starling, Anne P., Kechris, Katerina J., Yang, Ivana V., DeMeo, Dawn L., Litonjua, Augusto A., Baccarelli, Andrea, Oken, Emily, Holloway, John W., Karmaus, Wilfried, Arshad, Syed H., Dabelea, Dana, Sorensen, Thorkild I. A., Laivuori, Hannele, Räikkönen, Katri, Felix, Janine F., London, Stephanie J., Hivert, Marie-France, Gaunt, Tom R., Lawlor, Debbie A., Relton, Caroline L. |
| المساهمون: |
Doctoral Programme in Cognition, Learning, Instruction and Communication, Department of Psychology and Logopedics, Developmental Psychology Research Group, Helsinki Collegium for Advanced Studies, University of Helsinki, HUS Gynecology and Obstetrics, Genomics of Neurological and Neuropsychiatric Disorders, Institute for Molecular Medicine Finland, Pregnancy and Genes, University Management, Department of Medical and Clinical Genetics, Helsinki Institute of Life Science HiLIFE, Faculty of Medicine |
| بيانات النشر: |
Lippincott williams & wilkins |
| سنة النشر: |
2019 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
cardiovascular diseases, DNA methylation, gestational age, hypertension, preeclampsia, BLOOD-PRESSURE, FETAL-GROWTH, NORWEGIAN MOTHER, GENERATION R, COHORT, BIRTH, ASSOCIATIONS, HYPOMETHYLATION, METAANALYSIS, VASOPRESSIN, 3121 General medicine, internal medicine and other clinical medicine |
| الوصف: |
Hypertensive disorders of pregnancy (HDP) are associated with low birth weight, shorter gestational age, and increased risk of maternal and offspring cardiovascular diseases later in life. The mechanisms involved are poorly understood, but epigenetic regulation of gene expression may play a part. We performed meta-analyses in the Pregnancy and Childhood Epigenetics Consortium to test the association between either maternal HDP (10 cohorts; n=5242 [cases=476]) or preeclampsia (3 cohorts; n=2219 [cases=135]) and epigenome-wide DNA methylation in cord blood using the Illumina HumanMethylation450 BeadChip. In models adjusted for confounders, and with Bonferroni correction, HDP and preeclampsia were associated with DNA methylation at 43 and 26 CpG sites, respectively. HDP was associated with higher methylation at 27 (63%) of the 43 sites, and across all 43 sites, the mean absolute difference in methylation was between 0.6% and 2.6%. Epigenome-wide associations of HDP with offspring DNA methylation were modestly consistent with the equivalent epigenome-wide associations of preeclampsia with offspring DNA methylation (R-2=0.26). In longitudinal analyses conducted in 1 study (n=108 HDP cases; 550 controls), there were similar changes in DNA methylation in offspring of those with and without HDP up to adolescence. Pathway analysis suggested that genes located at/near HDP-associated sites may be involved in developmental, embryogenesis, or neurological pathways. HDP is associated with offspring DNA methylation with potential relevance to development. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Kazmi , N , Sharp , G C , Reese , S E , Vehmeijer , F O , Lahti , J , Page , C M , Zhang , W , Rifas-Shiman , S L , Rezwan , F I , Simpkin , A J , Burrows , K , Richardson , T G , Ferreira , D L S , Fraser , A , Harmon , Q E , Zhao , S , Jaddoe , V W V , Czamara , D , Binder , E B , Magnus , M C , Haberg , S E , Nystad , W , Nohr , E A , Starling , A P , Kechris , K J , Yang , I V , DeMeo , D L , Litonjua , A A , Baccarelli , A , Oken , E , Holloway , J W , Karmaus , W , Arshad , S H , Dabelea , D , Sorensen , T I A , Laivuori , H , Räikkönen , K , Felix , J F , London , S J , Hivert , M-F , Gaunt , T R , Lawlor , D A & Relton , C L 2019 , ' Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns Findings From the Pregnancy and Childhood Epigenetics Consortium ' , Hypertension , vol. 74 , no. 2 , pp. 375-383 . https://doi.org/10.1161/HYPERTENSIONAHA.119.12634Test; ORCID: /0000-0002-4310-5297/work/63682449; ORCID: /0000-0003-3124-3470/work/63683670; ea3c8db1-f0cd-4b9c-920e-aaed9714d0e1; http://hdl.handle.net/10138/306341Test; 000478894000034 |
| الإتاحة: |
http://hdl.handle.net/10138/306341Test |
| حقوق: |
cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.D83ACB14 |
| قاعدة البيانات: |
BASE |
