دورية أكاديمية
11 C-Acetate PET/CT Detects Reactive Astrogliosis Helping Glioma Classification
| العنوان: | 11 C-Acetate PET/CT Detects Reactive Astrogliosis Helping Glioma Classification |
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| المساهمون: | Dongwoo Kim, Joong Hyun Chun, Ju Hyeon Yi, Hae Young Ko, Jee-In Chung, Misu Lee, Yongmin Mason Park, Min-Ho Nam, Jisu Kim, Seon Yoo Kim, Youngjoo Park, Ju Hyung Moon, Seok-Gu Kang, Jong Hee Chang, C Justin Lee, Se Hoon Kim, Mijin Yun, Kang, Seok Gu |
| بيانات النشر: | Lippincott |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Acetates, Brain Neoplasms* / metabolism, Glioma* / pathology, Gliosis, Humans, Isocitrate Dehydrogenase / genetics, Isocitrate Dehydrogenase / metabolism, Mutation, Positron Emission Tomography Computed Tomography, Prospective Studies, Tumor Microenvironment |
| الوصف: | Purpose: 11 C-acetate ( 11 C-ACE) uptake on PET/CT was recently discovered to represent reactive astrocytes in the tumor microenvironment. This study aimed at evaluating the role of 11 C-ACE PET/CT as an imaging biomarker of reactive astrogliosis in characterizing different types of gliomas. Methods: In this prospective study, a total of 182 patients underwent 11 C-ACE PET/CT before surgery. The ratio of SUV max of a glioma to the SUV mean of the contralateral choroid plexus ( 11 C-ACE TCR) on PET/CT was calculated. 11 C-ACE TCRs were compared with the World Health Organization grades and isocitrate dehydrogenase 1 ( IDH1 ) mutation status. Grade 2 was considered low-grade tumor, and grades 3 and 4 were considered high-grade tumors. Results: The median 11 C-ACE TCR was significantly higher in IDH1 wild-type (wt) tumors (n = 91) than in IDH1 -mutant (mt) tumors (n = 91) (2.38 vs 1.30, P < 0.001). Of the 91 IDH1 -mt tumors, there were no differences in the median 11 C-ACE TCRs between oligodendrogliomas (ODs) and astrocytic tumors (1.40 vs 1.20, P > 0.05). In grading low- versus high-grade gliomas, the receiver operating characteristic curve analyses showed a higher area under the curve (0.951) in IDH1 -wt tumors than in IDH1 -mt tumors (0.783, P = 0.002). Grade 2 ODs were well differentiated from high-grade gliomas. The 11 C-ACE TCR of grade 3 ODs was significantly lower than that of IDH1 -wt glioblastomas. Conclusions: High 11 C-ACE uptake is associated with high-grade IDH1 -wt tumors, thus facilitating differentiation from high-grade IDH1-mt and low-grade gliomas. In particular, low 11 C-ACE uptake in ODs is advantageous in overcoming the limitation of radiolabeled amino acid tracers. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0363-9762 1536-0229 |
| العلاقة: | CLINICAL NUCLEAR MEDICINE; J00595; OAK-2022-08188; OAK-2022-08189; OAK-2022-08190; OAK-2022-08191; OAK-2022-08192; OAK-2022-08193; https://ir.ymlib.yonsei.ac.kr/handle/22282913/192185Test; https://journals.lww.com/nuclearmed/Fulltext/2022/10000/11C_Acetate_PET_CT_Detects_Reactive_Astrogliosis.4.aspxTest; T202204402; CLINICAL NUCLEAR MEDICINE, Vol.47(10) : 863-868, 2022-10 |
| DOI: | 10.1097/rlu.0000000000004341 |
| الإتاحة: | https://doi.org/10.1097/rlu.0000000000004341Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/192185Test https://journals.lww.com/nuclearmed/Fulltext/2022/10000/11C_Acetate_PET_CT_Detects_Reactive_Astrogliosis.4.aspxTest |
| حقوق: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.E6FD9362 |
| قاعدة البيانات: | BASE |
| تدمد: | 03639762 15360229 |
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| DOI: | 10.1097/rlu.0000000000004341 |