دورية أكاديمية
Life Science Alliance / The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner
| العنوان: | Life Science Alliance / The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner |
|---|---|
| المؤلفون: | Heberle, AM, Razquin Navas, P, Langelaar-Makkinje, M, Kasack, K, Sadik, A, Faessler, E, Hahn, U, Marx-Stoelting, P, Opitz, CA, Sers, C, Heiland, I, Schäuble, S, Thedieck, K |
| بيانات النشر: | Life Science Alliance LLC |
| سنة النشر: | 2019 |
| المجموعة: | University of Innsbruck: Digital Library (Universitäts- und Landesbibliothek Tirol) |
| جغرافية الموضوع: | UI:CP:BE, UI:AE:MC |
| الوصف: | All cells and organisms exhibit stress-coping mechanisms to ensure survival. Cytoplasmic protein-RNA assemblies termed stress granules are increasingly recognized to promote cellular survival under stress. Thus, they might represent tumor vulnerabilities that are currently poorly explored. The translation-inhibitory eIF2α[alpha] kinases are established as main drivers of stress granule assembly. Using a systems approach, we identify the translation enhancers PI3K and MAPK/p38 as pro-stress-granule-kinases. They act through the metabolic master regulator mammalian target of rapamycin complex 1 (mTORC1) to promote stress granule assembly. When highly active, PI3K is the main driver of stress granules; however, the impact of p38 becomes apparent as PI3K activity declines. PI3K and p38 thus act in a hierarchical manner to drive mTORC1 activity and stress granule assembly. Of note, this signaling hierarchy is also present in human breast cancer tissue. Importantly, only the recognition of the PI3K-p38 hierarchy under stress enabled the discovery of p38’s role in stress granule formation. In summary, we assign a new pro-survival function to the key oncogenic kinases PI3K and p38, as they hierarchically promote stress granule formation. ; Europäische Kommission H2020 754688 ; Version of record |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 2575-1077 |
| العلاقة: | vignette : https://diglib.uibk.ac.at/titlepage/urn/urn:nbn:at:at-ubi:3-15496/128Test; urn:nbn:at:at-ubi:3-15496; https://resolver.obvsg.at/urn:nbn:at:at-ubi:3-15496Test; local:99145888252503331; system:AC16159258 |
| DOI: | 10.26508/lsa.201800257 |
| الإتاحة: | https://doi.org/10.26508/lsa.201800257Test https://resolver.obvsg.at/urn:nbn:at:at-ubi:3-15496Test |
| حقوق: | cc-by_4 |
| رقم الانضمام: | edsbas.EA7B68A0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 25751077 |
|---|---|
| DOI: | 10.26508/lsa.201800257 |