التفاصيل البيبلوغرافية
| العنوان: |
The Sequence and Analysis of Duplication Rich Human Chromosome 16 |
| المؤلفون: |
Martin, Joel, Han, Cliff, Gordon, Laurie A., Terry, Astrid, Prabhakar, Shyam, She, Xinwei, Xie, Gary, Hellsten, Uffe, Chan, Yee Man, Altherr, Michael, Couronne, Olivier, Aerts, Andrea, Bajorek, Eva, Black, Stacey, Blumer, Heather, Branscomb, Elbert, Brown, Nancy C., Bruno, William J., Buckingham, Judith, Callen, David F., Campbell, Connie S., Campbell, Mary L., Campbell, Evelyn W., Caoile, Chenier, Challacombe, Jean F., Chasteen, Lesile A., Chertkov, Olga, Chi, Han C., Christensen, Mari, Clark, Lynn M., Cohn, Judith D., Denys, Mirian, Detter, John C., Dickson, Mark, Dimitrijevic-Bussod, Mira, Escobar, Julio, Fawcett, Joseph J., Flowers, Dave, Fotopulos, Dea, Glavina, Tijina, Gomez, Maria, Gonzales, Eidelyn, Goodstein, David, Goodwin, Lynne A., Grady, Debroah L., Grigoriev, Igor, Groza, Matthew, Hammon, Nancy, Hawkins, Trevor, Haydu, Lauren, Hildebrand, Carl E., Huang, Wayne, Israni, Sanjay, Jett, Jamie, Jewett, Philip E., Kadner, Kristen, Kimball, Heather, Kobayashi, Arthur, Krawczyk, Marie-Claude, Leyba, Tina, Longmire, Jonathan L., Lopez, Frederick, Lou, Yunian, Lowry, Steve, Ludeman, Thom, Manohar, Chitra F., Mark, Graham A., McMurray, Kimberly L., Meincke, Linda J., Morgan, Jenna, Moyzis, Robert K., Mundt, Mark O., Munk, A. Christine, Nandkeshwar, Richard D., Pitluck, Sam, Pollard, Martin, Predki, Paul, Parson-Quintana, Beverly, Ramirez, Lucia, Rash, Sam, Retterer, James, Ricke, Darryl O., Robinson, Donna, Rodriguez, Alex, Salamov, Asaf, Saunders, Elizabeth H., Scott, Duncan, Shough, Timothy, Stallings, Raymond L., Stalvey, Malinda, Sutherland, Robert D., Tapia, Roxanne, Tesmer, Judith G., Thayer, Nina, Thompson, Linda S., Tice, Hope, Torney, David C., Tran-Gyamfi, Mary, Tsai, Ming, Ulanovsky, Levy E., Ustaszewska, Anna, Vo, Nu, White, P. Scott, Williams, Albert L., Wills, Patricia L., Wu, Jung-Rung, Wu, Kevin, Yang, Joan, DeJong, Pieter, Bruce, David, Doggett, Norman A., Deaven, Larry, Schmutz, Jeremy, Grimwood, Jane, Richardson, Paul, Rokhsar, Daniel S., Eichler, Evan E., Gilna, Paul, Lucas, Susan M., Myers, Richard M., Rubin, Edward M., Pennacchio, Len A. |
| المساهمون: |
United States. Department of Energy. |
| المصدر: |
Journal Name: Nature; Journal Volume: 432 |
| بيانات النشر: |
Lawrence Livermore National Laboratory |
| سنة النشر: |
2005 |
| المجموعة: |
University of North Texas: UNT Digital Library |
| مصطلحات موضوعية: |
Chromosomes, Diseases, Genes, Leukemia, 59 Basic Biological Sciences, Rna, Metallothionein, Human Chromosome 16, Kidneys, Primates |
| الوصف: |
Human chromosome 16 features one of the highest levels of segmentally duplicated sequence among the human autosomes. We report here the 78,884,754 base pairs of finished chromosome 16 sequence, representing over 99.9% of its euchromatin. Manual annotation revealed 880 protein-coding genes confirmed by 1,637 aligned transcripts, 19 tRNA genes, 341 pseudogenes, and 3 RNA pseudogenes. These genes include metallothionein, cadherin, and iroquois gene families, as well as the disease genes for polycystic kidney disease and acute myelomonocytic leukemia. Several large-scale structural polymorphisms spanning hundreds of kilobase pairs were identified and result in gene content differences among humans. While the segmental duplications of chromosome 16 are enriched in the relatively gene poor pericentromere of the p-arm, some are involved in recent gene duplication and conversion events likely to have had an impact on the evolution of primates and human disease susceptibility. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
PDF-file: 31 pages; size: 0.5 Mbytes; Text |
| اللغة: |
English |
| العلاقة: |
rep-no: UCRL-JRNL-211171; grantno: W-7405-ENG-48; osti: 875361; https://digital.library.unt.edu/ark:/67531/metadc878367Test/; ark: ark:/67531/metadc878367 |
| الإتاحة: |
https://digital.library.unt.edu/ark:/67531/metadc878367Test/ |
| رقم الانضمام: |
edsbas.BD7F26BE |
| قاعدة البيانات: |
BASE |
