SOCS3
| العنوان: | SOCS3 |
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| المؤلفون: | Yasukawa, Hideo, Nagata, Takanobu, Oba, Toyoharu, Imaizumi, Tsutomu |
| المصدر: | JAK-STAT |
| بيانات النشر: | Landes Bioscience, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | myocardial infarction, cardioprotection, cytokine, cytokine resistance, SOCS1, Review, SOCS3, JAK-STA |
| الوصف: | The suppressors of cytokine signaling (SOCS) family of proteins are cytokine-inducible inhibitors of Janus kinase (JAK)-signal transducer and activator of the transcription (STAT) signaling pathways. Among the family, SOCS1 and SOCS3 potently suppress cytokine actions by inhibiting JAK kinase activities. The generation of mice lacking individual SOCS genes has been instrumental in defining the role of individual SOCS proteins in specific cytokine pathways in vivo; SOCS1 is an essential negative regulator of interferon-γ (IFNγ) and SOCS3 is an essential negative regulator of leukemia inhibitory factor (LIF). JAK-STAT3 activating cytokines have exhibited cardioprotective roles in the heart. The cardiac-specific deletion of SOCS3 enhances the activation of cardioprotective signaling pathways, inhibits myocardial apoptosis and fibrosis and results in the inhibition of left ventricular remodeling after myocardial infarction (MI). We propose that myocardial SOCS3 is a key determinant of left ventricular remodeling after MI, and SOCS3 may serve as a novel therapeutic target to prevent left ventricular remodeling after MI. In this review, we discuss the signaling pathways mediated by JAK-STAT and SOCS proteins and their roles in the development of myocardial injury under stress (e.g., pressure overload, viral infection and ischemia). |
| اللغة: | English |
| تدمد: | 2162-3996 2162-3988 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::25ac29d9532a9a600b8c6d77ce85a12cTest http://europepmc.org/articles/PMC3670279Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........25ac29d9532a9a600b8c6d77ce85a12c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21623996 21623988 |
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