التفاصيل البيبلوغرافية
| العنوان: |
Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial. |
| المؤلفون: |
Powles, Thomas1 thomas.powles@bartshealth.nhs.uk, Durán, Ignacio2,3, van der Heijden, Michiel S.4, Loriot, Yohann5, Vogelzang, Nicholas J.6, De Giorgi, Ugo7, Oudard, Stéphane8, Retz, Margitta M.9, Castellano, Daniel10, Bamias, Aristotelis11, Fléchon, Aude12, Gravis, Gwenaëlle13, Hussain, Syed14, Toshimi Takano15, Ning Leng16, Kadel III, Edward E.16, Banchereau, Romain16, Hegde, Priti S.16, Mariathasan, Sanjeev16, Na Cui16 |
| المصدر: |
Lancet. 2/24/2018, Vol. 391 Issue 10122, p748-757. 10p. |
| مصطلحات موضوعية: |
*RESEARCH, CANCER treatment, PUBLIC health, ANTINEOPLASTIC agents, RANDOMIZED controlled trials, CANCER chemotherapy, CANCER-related mortality, HYDROCARBONS, THERAPEUTIC use of monoclonal antibodies, PACLITAXEL, CANCER, COMPARATIVE studies, RESEARCH methodology, MEDICAL cooperation, URINARY organs, VINBLASTINE, EVALUATION research, TREATMENT effectiveness, TUMORS, THERAPEUTICS |
| مستخلص: |
Background: Few options exist for patients with locally advanced or metastatic urothelial carcinoma after progression with platinum-based chemotherapy. We aimed to assess the safety and efficacy of atezolizumab (anti-programmed death-ligand 1 [PD-L1]) versus chemotherapy in this patient population.Methods: We conducted this multicentre, open-label, phase 3 randomised controlled trial (IMvigor211) at 217 academic medical centres and community oncology practices mainly in Europe, North America, and the Asia-Pacific region. Patients (aged ≥18 years) with metastatic urothelial carcinoma who had progressed after platinum-based chemotherapy were randomly assigned (1:1), via an interactive voice and web response system with a permuted block design (block size of four), to receive atezolizumab 1200 mg or chemotherapy (physician's choice: vinflunine 320 mg/m2, paclitaxel 175 mg/m2, or 75 mg/m2 docetaxel) intravenously every 3 weeks. Randomisation was stratified by PD-L1 expression (expression on <1% [IC0] or 1% to <5% [IC1] of tumour-infiltrating immune cells vs ≥5% of tumour-infiltrating immune cells [IC2/3]), chemotherapy type (vinflunine vs taxanes), liver metastases (yes vs no), and number of prognostic factors (none vs one, two, or three). Patients and investigators were aware of group allocation. Patients, investigators, and the sponsor were masked to PD-L1 expression status. The primary endpoint of overall survival was tested hierarchically in prespecified populations: IC2/3, followed by IC1/2/3, followed by the intention-to-treat population. This study, which is ongoing but not recruiting participants, is registered with ClinicalTrials.gov, number NCT02302807.Findings: Between Jan 13, 2015, and Feb 15, 2016, we randomly assigned 931 patients from 198 sites to receive atezolizumab (n=467) or chemotherapy (n=464). In the IC2/3 population (n=234), overall survival did not differ significantly between patients in the atezolizumab group and those in the chemotherapy group (median 11·1 months [95% CI 8·6-15·5; n=116] vs 10·6 months [8·4-12·2; n=118]; stratified hazard ratio [HR] 0·87, 95% CI 0·63-1·21; p=0·41), thus precluding further formal statistical analysis. Confirmed objective response rates were similar between treatment groups in the IC2/3 population: 26 (23%) of 113 evaluable patients had an objective response in the atezolizumab group compared with 25 (22%) of 116 patients in the chemotherapy group. Duration of response was numerically longer in the atezolizumab group than in the chemotherapy group (median 15·9 months [95% CI 10·4 to not estimable] vs 8·3 months [5·6-13·2]; HR 0·57, 95% CI 0·26-1·26). In the intention-to-treat population, patients receiving atezolizumab had fewer grade 3-4 treatment-related adverse events than did those receiving chemotherapy (91 [20%] of 459 vs 189 [43%] of 443 patients), and fewer adverse events leading to treatment discontinuation (34 [7%] vs 78 [18%] patients).Interpretation: Atezolizumab was not associated with significantly longer overall survival than chemotherapy in patients with platinum-refractory metastatic urothelial carcinoma overexpressing PD-L1 (IC2/3). However, the safety profile for atezolizumab was favourable compared with chemotherapy, Exploratory analysis of the intention-to-treat population showed well-tolerated, durable responses in line with previous phase 2 data for atezolizumab in this setting.Funding: F Hoffmann-La Roche, Genentech. [ABSTRACT FROM AUTHOR] |
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