Comparative Analysis of Ileal and Cecal Microbiota in Aged Rats
| العنوان: | Comparative Analysis of Ileal and Cecal Microbiota in Aged Rats |
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| المؤلفون: | Ji Hyun Park, Ryoung Hee Nam, Nayoung Kim, Dong Ho Lee, Sun Min Lee, Kichul Yoon |
| المصدر: | Journal of Cancer Prevention |
| بيانات النشر: | Korean Society of Cancer Prevention, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Aging, Physiology, Ileum, Gut flora, digestive system, 03 medical and health sciences, Cecum, fluids and secretions, medicine, Gastrointestinal microbiome, Gastrointestinal tract, biology, digestive, oral, and skin physiology, Lachnospiraceae, Gastrointestinal Microbiome, biology.organism_classification, Gut microbiome, Rats, stomatognathic diseases, 030104 developmental biology, medicine.anatomical_structure, Original Article, Ruminococcaceae |
| الوصف: | Background Gut microbiota contributes to intestinal and immune homeostasis through host-microbiota interactions. Distribution of the gut microbiota differs according to the location in the gastrointestinal tract. Although the microbiota properties change with age, evidence for the regional difference of gut microbiota has been restricted to the young. The aim of this study is to compare the gut microbiota between terminal ileum and cecum of old rats. Methods We analyzed gut microbiome of luminal contents from ileum and cecum of 74-week-old and 2-year-old rats (corresponding to 60-year and 80-year-old of human age) by metagenome sequencing of 16S rRNA. Results Inter-individual variation (beta diversity) of microbiota was higher in ileum than in cecum. Conversely, alpha diversity of microbiota composition was higher in cecum than in ileum. Lactobacillaceae were more abundant in ileum compared to cecum while Ruminococcaceae and Lachnospiraceae were more enriched in cecum. The proportions of Deltaproteobacteria were increased in cecal microbiota of 2-year-old rats compared to 74-week-old rats. Conclusions Major regional distinctions of microbiota between ileum and cecum of old rats appear consistent with those of young rats. Age-related alterations of gut microbiota in old rats seem to occur in minor compositions. |
| تدمد: | 2288-3657 2288-3649 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10e29be8dd2fde127949c2f688d1560Test https://doi.org/10.15430/jcp.2018.23.2.70Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c10e29be8dd2fde127949c2f688d1560 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22883657 22883649 |
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