Biological Roles of Alternative Autophagy
| العنوان: | Biological Roles of Alternative Autophagy |
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| المؤلفون: | Shimizu, Shigeomi |
| المصدر: | Molecules and Cells |
| بيانات النشر: | Korean Society for Molecular and Cellular Biology, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | alternative autophagy, Golgi membrane, proteolysis, Autophagosomes, erythrocyte maturation, Autophagy-Related Protein 7, Models, Biological, Autophagy-Related Protein 5, Phagosomes, Autophagy, Animals, Humans, Minireview, Atg5, Lysosomes, Microtubule-Associated Proteins |
| الوصف: | Atg5 and Atg7 have long been considered as essential molecules for autophagy. However, we found that cells lacking these molecules still form autophagic vacuoles and perform autophagic protein degradation when subjected to certain stressors. During this unconventional autophagy pathway, autophagosomes appeared to be generated in a Rab9-dependent manner by the fusion of vesicles derived from the trans-Golgi and late endosomes. Therefore, mammalian autophagy can occur via at least two different pathways; the Atg5/Atg7-dependent conventional pathway and an Atg5/Atg7-independent alternative pathway. |
| اللغة: | English |
| تدمد: | 0219-1032 1016-8478 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::577d7f9d26eda380544b6a4a195a44dbTest http://europepmc.org/articles/PMC5792713Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........577d7f9d26eda380544b6a4a195a44db |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02191032 10168478 |
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