Dysfunctional Patterns of Gamma-Band Activity in Response to Human Faces Compared to Non-Facial Stimuli in Patients with Schizophrenia
| العنوان: | Dysfunctional Patterns of Gamma-Band Activity in Response to Human Faces Compared to Non-Facial Stimuli in Patients with Schizophrenia |
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| المؤلفون: | Do-Won Kim, Chang-Hwan Im, Seung Hwan Lee, Mi Seon Shim, Sangrae Kim |
| المصدر: | Psychiatry Investigation |
| بيانات النشر: | Korean Neuropsychiatric Association, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | medicine.medical_specialty, 05 social sciences, Dysfunctional family, Audiology, medicine.disease, 050105 experimental psychology, Developmental psychology, Phase synchronization, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, High-beta-band activity, Schizophrenia, Healthy individuals, Gamma-band activity, medicine, Human faces, Original Article, 0501 psychology and cognitive sciences, In patient, Psychology, Gamma band, 030217 neurology & neurosurgery, Biological Psychiatry |
| الوصف: | Objective Healthy individuals show stronger gamma-band activities (GBAs) for socially relevant stimuli (human faces) than for non-relevant ones. This study aimed to examine whether this gamma-band preference occurs in patients with schizophrenia. Methods EEG was recorded for 24 patients with schizophrenia and 23 healthy controls while they viewed pictures of human faces, chairs, and nature scenes. The spectral powers of high-beta (20–30 Hz) and gamma (30–80 Hz) frequencies were analyzed along 3 midline cortical regions, and phase synchronization was calculated. Results Compared to the response to non-facial stimuli, higher event related deactivation to facial stimuli was observed for the high-beta frequency across groups. For the gamma frequency, early-stage GBA was increased and late-stage GBA was decreased for all 3 stimuli in patients with schizophrenia compared to healthy controls. Preferential GBA patterns (100–200 and 200–300 ms) were found in healthy controls, but not in patients with schizophrenia. Significant correlation existed between negative symptoms and GBA in the frontal region for chair and scene stimuli. There was no significant intergroup difference in phase synchronization pattern. Conclusion Our results suggest that patients with schizophrenia have deficits in the preferential pattern of GBA for human faces and the deficits in the preferential pattern were mainly influenced by over-response to socially non-relevant stimuli. |
| تدمد: | 1976-3026 1738-3684 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1d4fdac603318c286300ad55243e6fTest https://doi.org/10.4306/pi.2016.13.3.349Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eb1d4fdac603318c286300ad55243e6f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19763026 17383684 |
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