T2 Relaxometry Using 3.0-Tesla Magnetic Resonance Imaging of the Brain in Early- and Late-Onset Restless Legs Syndrome
| العنوان: | T2 Relaxometry Using 3.0-Tesla Magnetic Resonance Imaging of the Brain in Early- and Late-Onset Restless Legs Syndrome |
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| المؤلفون: | Yong Won Cho, Hyuk Won Chang, Hye Jin Moon, Hee Jin Song, Yongmin Chang, Jeonghun Ku, Yeong Seon Lee |
| المصدر: | Journal of Clinical Neurology (Seoul, Korea) |
| بيانات النشر: | Korean Neurological Association, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | T2 relaxometry, medicine.medical_specialty, Pathology, Red nucleus, Late onset, iron, Disease severity, Internal medicine, Magnetic resonance imaging of the brain, mental disorders, medicine, Restless legs syndrome, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Iron deficiency, medicine.disease, Neurology, substantia nigra, Cardiology, restless legs syndrome, Original Article, red nucleus, Neurology (clinical), business |
| الوصف: | Background and purpose Previous T2 relaxometry studies have provided evidence for regional brain iron deficiency in patients with restless legs syndrome (RLS). Measurement of the iron content in several brain regions, and in particular the substantia nigra (SN), in early- and late-onset RLS patients using T2 relaxometry have yielded inconsistent results. In this study the regional iron content was assessed in patients with early- and late-onset RLS using magnetic resonance imaging (MRI), and compared the results with those in controls. Methods Thirty-seven patients with idiopathic RLS (20 with early onset and 17 with late onset) and 40 control subjects were studied using a 3.0-tesla MRI with a gradient-echo sampling of free induction decay and echo pulse sequence. The regions of interest in the brain were measured independently by two trained analysts using software known as medical image processing, analysis, and visualization. The results were compared and a correlation analysis was conducted to investigate which brain areas were related to RLS clinical variables. Results The iron index in the SN was significantly lower in patients with late-onset RLS than in controls (p=0.034), while in patients with early-onset RLS there was no significant difference. There was no significant correlation between the SN iron index of the late-onset RLS group and clinical variables such as disease severity. Conclusions Late-onset RLS is associated with decreased iron content in the SN. This finding supports the hypothesis that regional brain iron deficiency plays a role in the pathophysiology of late-onset RLS. |
| اللغة: | English |
| تدمد: | 2005-5013 1738-6586 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611ab2b3c211864a9102fe9105f0b7d2Test http://europepmc.org/articles/PMC4101095Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....611ab2b3c211864a9102fe9105f0b7d2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20055013 17386586 |
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