Comparison of Serum PCSK9 Levels in Subjects with Normoglycemia, Impaired Fasting Glucose, and Impaired Glucose Tolerance
| العنوان: | Comparison of Serum PCSK9 Levels in Subjects with Normoglycemia, Impaired Fasting Glucose, and Impaired Glucose Tolerance |
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| المؤلفون: | Eugene Han, Nan Hee Cho, Hochan Cho, Seong-Su Moon |
| المصدر: | Endocrinology and Metabolism Endocrinology and Metabolism, Vol 35, Iss 2, Pp 480-483 (2020) |
| بيانات النشر: | Korean Endocrine Society, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Pilot Projects, 030209 endocrinology & metabolism, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Prediabetic State, Impaired glucose tolerance, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal medicine, Glucose Intolerance, Republic of Korea, medicine, Humans, Prediabetes, Aged, Glucose tolerance test, lcsh:RC648-665, medicine.diagnostic_test, business.industry, Brief Report, PCSK9, nutritional and metabolic diseases, Prognosis, medicine.disease, Impaired fasting glucose, Metabolic syndrome, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Pro-protein convertase subtilisin-kexin type 9, Case-Control Studies, 030220 oncology & carcinogenesis, Female, Analysis of variance, Insulin Resistance, Proprotein Convertase 9, business, Biomarkers, hormones, hormone substitutes, and hormone antagonists, Follow-Up Studies |
| الوصف: | We investigated proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations in individuals with normoglycemia, impaired fasting glucose (IFG), and impaired glucose tolerance (IGT). This was a pilot, cross-sectional study including 92 individuals who had not been diagnosed with or treated for diabetes. We measured PCSK9 levels in three groups of subjects; namely, normoglycemia (n=57), IFG (n=21), and IGT (n=14). Individuals with IFG and IGT showed higher PCSK9 concentrations than those in the normoglycemic group, with the highest serum PCSK9 concentrations found in individuals with IGT (55.25±15.29 ng/mL for normoglycemia, 63.47±17.78 ng/mL for IFG, 72.22±15.46 ng/mL for IGT, analysis of variance P=0.001). There were no significant differences in high- or low-density lipoprotein cholesterol among groups. Serum PCSK9 levels are increased in patients with prediabetes compared to subjects with normoglycemia. |
| تدمد: | 2093-5978 2093-596X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550732f2ab78cacac9643996001228beTest https://doi.org/10.3803/enm.2020.35.2.480Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....550732f2ab78cacac9643996001228be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20935978 2093596X |
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