المؤلفون: Qianwen Huang¹, Daizhi Yang¹, Hongrong Deng¹, Hua Liang¹, Xueying Zheng², Jinhua Yan¹, Wen Xu¹, Xiangwen Liu¹, Bin Yao¹, Sihui Luo² luosihui@ustc.edu.cn, Jianping Weng^1,2

المصدر: Diabetes & Metabolism Journal. Jan2022, Vol. 46 Issue 1, p93-103. 14p.

مصطلحات موضوعية: *TYPE 1 diabetes, *DIABETIC retinopathy, *GLYCOSYLATED hemoglobin, *METABOLIC syndrome, *DIABETIC nephropathies, *ADULTS, *INSULIN pumps

مصطلحات جغرافية: CHINA

مستخلص: Background: Both type 1 diabetes mellitus (T1DM) and metabolic syndrome (MetS) are associated with an elevated risk of morbidity and mortality yet with increasing heterogeneity. This study primarily aimed to evaluate the prevalence of MetS among adult patients with T1DM in China and investigate its associated risk factors, and relationship with microvascular complications. Methods: We included adult patients who had been enrolled in the Guangdong T1DM Translational Medicine Study conducted from June 2010 to June 2015. MetS was defined according to the updated National Cholesterol Education Program criterion. Logistic regression models were used to estimate the odds ratio (OR) for the association between MetS and the risk of diabetic kidney disease (DKD) and diabetic retinopathy (DR). Results: Among the 569 eligible patients enrolled, the prevalence of MetS was 15.1%. While female gender, longer diabetes duration, higher body mass index, and glycosylated hemoglobin A1c (HbA1c) were risk factors associated with MetS (OR, 2.86, 1.04, 1.14, and 1.23, respectively), received nutrition therapy education was a protective factor (OR, 0.46). After adjustment for gender, age, diabetes duration, HbA1c, socioeconomic and lifestyle variables, MetS status was associated with an increased risk of DKD and DR (OR, 2.14 and 3.72, respectively; both P<0.05). Conclusion: Although the prevalence of MetS in adult patients with T1DM in China was relatively low, patients with MetS were more likely to have DKD and DR. A comprehensive management including lifestyle modification might reduce their risk of microvascular complications in adults with T1DM. [ABSTRACT FROM AUTHOR]

المؤلفون: Jinhua Yan, Jianping Weng, Bin Yao, Xueying Zheng, Sihui Luo, Hua Liang, Qianwen Huang, Hongrong Deng, Xiangwen Liu, Daizhi Yang, Wen Xu

المصدر: Diabetes & Metabolism Journal, Vol 46, Iss 1, Pp 93-103 (2022)

مصطلحات موضوعية: Male, medicine.medical_specialty, diabetic nephropathies, endocrine system diseases, Endocrinology, Diabetes and Metabolism, metabolic syndrome, Diseases of the endocrine glands. Clinical endocrinology, Diabetes mellitus, Internal medicine, Medicine, Humans, Medical nutrition therapy, National Cholesterol Education Program, Glycated Hemoglobin, Type 1 diabetes, business.industry, adult, Odds ratio, Diabetic retinopathy, medicine.disease, RC648-665, diabetic retinopathy, diabetes mellitus, type 1, Female, Metabolic syndrome, business, Body mass index

الوصف: Background: Both type 1 diabetes mellitus (T1DM) and metabolic syndrome (MetS) are associated with an elevated risk of morbidity and mortality yet with increasing heterogeneity. This study primarily aimed to evaluate the prevalence of MetS among adult patients with T1DM in China and investigate its associated risk factors, and relationship with microvascular complications.Methods: We included adult patients who had been enrolled in the Guangdong T1DM Translational Medicine Study conducted from June 2010 to June 2015. MetS was defined according to the updated National Cholesterol Education Program criterion. Logistic regression models were used to estimate the odds ratio (OR) for the association between MetS and the risk of diabetic kidney disease (DKD) and diabetic retinopathy (DR).Results: Among the 569 eligible patients enrolled, the prevalence of MetS was 15.1%. While female gender, longer diabetes duration, higher body mass index, and glycosylated hemoglobin A1c (HbA1c) were risk factors associated with MetS (OR, 2.86, 1.04, 1.14, and 1.23, respectively), received nutrition therapy education was a protective factor (OR, 0.46). After adjustment for gender, age, diabetes duration, HbA1c, socioeconomic and lifestyle variables, MetS status was associated with an increased risk of DKD and DR (OR, 2.14 and 3.72, respectively; both P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cc0744ff91b4098b6b8c2e51b98b81Test
http://www.e-dmj.org/upload/pdf/dmj-2020-0240.pdfTest

المؤلفون: Zhiguang Zhou, Yu Liu, Gan Huang, Qing Liu, Jing Zou, Li Qian, Ying Zhou, Yuxiao Zhu, Tao Yang

المصدر: Diabetes & Metabolism Journal, Vol 44, Iss 2, Pp 260-266 (2020)
Diabetes & Metabolism Journal

مصطلحات موضوعية: Adult, Male, endocrine system, Adolescent, endocrine system diseases, autoantibodies, Endocrinology, Diabetes and Metabolism, Glutamate decarboxylase, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, c-peptide, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Islets of Langerhans, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Diabetes mellitus, medicine, Humans, latent autoimmune diabetes in adults, Technology/Devise, Type 1 diabetes, lcsh:RC648-665, biology, business.industry, C-peptide, Autoantibody, Type 2 Diabetes Mellitus, nutritional and metabolic diseases, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, Phenotype, Diabetes Mellitus, Type 2, chemistry, Case-Control Studies, Immunology, biology.protein, glutamate decarboxylase, Female, Original Article, Radiobinding assay, Antibody, business

الوصف: Background: The detection of glutamic acid decarboxylase 65 (GAD65) autoantibodies is essential for the prediction and diag nosis of latent autoimmune diabetes in adults (LADA). The aim of the current study was to compare a newly developed electro chemiluminescence (ECL)-GAD65 antibody assay with the established radiobinding assay, and to explore whether the new assay could be used to define LADA more precisely. Methods: Serum samples were harvested from 141 patients with LADA, 95 with type 1 diabetes mellitus, and 99 with type 2 dia betes mellitus, and tested for GAD65 autoantibodies using both the radiobinding assay and ECL assay. A glutamic acid decarbox ylase antibodies (GADA) competition assay was also performed to assess antibody affinity. Furthermore, the clinical features of these patients were compared. Results: Eighty-eight out of 141 serum samples (62.4%) from LADA patients were GAD65 antibody-positive by ECL assay. Com pared with ECL-GAD65 antibody-negative patients, ECL-GAD65 antibody-positive patients were leaner (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2d9264896b26a9cda74d22d4eb90f4Test
http://e-dmj.org/upload/pdf/dmj-44-260.pdfTest

المؤلفون: Sang-Man Jin, Kyungdo Han, Jae Hyeon Kim, You-Bin Lee, Bongsung Kim, Ji Eun Jun, Seung Eun Lee, Gyuri Kim, Jiyeon Ahn

المصدر: Diabetes & Metabolism Journal
Diabetes & Metabolism Journal, Vol 43, Iss 1, Pp 76-89 (2018)

مصطلحات موضوعية: Adult, Male, endocrine system diseases, Epidemiology, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, Diabetes mellitus, Republic of Korea, medicine, Prevalence, Humans, In patient, education, Aged, Metabolic Syndrome, Type 1 diabetes, education.field_of_study, lcsh:RC648-665, Korea, business.industry, Incidence (epidemiology), Incidence, Preventive health, nutritional and metabolic diseases, Diabetes mellitus, type 1, Middle Aged, medicine.disease, National health insurance, Cardiovascular Diseases, Original Article, Female, Metabolic syndrome, business, human activities, Demography

الوصف: Background The prevalence and incidence of type 1 diabetes mellitus (T1DM) in all age groups and the prevalence of metabolic syndrome in patients with T1DM in Korea were estimated. Methods The incidence and prevalence of T1DM between 2007 and 2013 were calculated using the Korean National Health Insurance Service (NHIS) datasets of claims. Clinical characteristics and prevalence of metabolic syndrome in individuals with T1DM between 2009 and 2013 were determined using the database of NHIS preventive health checkups. Results The prevalence of T1DM in Korea between 2007 and 2013 was 0.041% to 0.047%. The annual incidence rate of T1DM in Korea in 2007 to 2013 was 2.73 to 5.02/100,000 people. Although the incidence rate of typical T1DM was highest in teenagers, it remained steady in adults over 30 years of age. In contrast, the incidence rate of atypical T1DM in 2013 was higher in people aged 40 years or older than in younger age groups. Age- and sex-adjusted prevalence of metabolic syndrome in patients with T1DM was 51.65% to 55.06% between 2009 and 2013. Conclusion T1DM may be more common in Korean adults than previously believed. Metabolic syndrome may be a frequent finding in individuals with T1DM in Korea.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff436ed53d194b399c78e250ec8c2376Test
http://europepmc.org/articles/PMC6387882Test

المؤلفون: Moon Kyu Lee, Sang-Man Jin, Sunyoung Kim, Kyu Yeon Hur, Hye Mi Lee, Jae Hyeon Kim, Kang Hee Sim, So-Young Park

المصدر: Diabetes & Metabolism Journal, Vol 41, Iss 2, Pp 99-112 (2017)
Diabetes & Metabolism Journal

مصطلحات موضوعية: Diabetes duration, Adult, medicine.medical_specialty, endocrine system diseases, Psychosocial outcome, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Diabetes self management, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Diabetes camp, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, medicine, Elderly people, 030212 general & internal medicine, Clinical Care/Education, Type 1 diabetes, lcsh:RC648-665, business.industry, Hemoglobin A, glycosylated, variability, Metabolic outcome, Continuing education, Type 2 Diabetes Mellitus, nutritional and metabolic diseases, medicine.disease, Endocrinology, Hemoglobin A, Original Article, business

الوصف: Background Despite the established benefits of diabetes camps for the continuing education of children with type 1 diabetes mellitus, little is known about the long-term metabolic benefits of diabetes camps for middle-aged and elderly people with type 2 diabetes mellitus (T2DM), especially in terms of glycosylated hemoglobin (HbA1c) variability. Methods The 1-year mean and variability of HbA1c before and after the diabetes camp was compared between the participants of the diabetes camp (n=57; median age 65 years [range, 50 to 86 years]; median diabetes duration 14 years [range, 1 to 48 years]). Additional case-control analysis compared the metabolic outcomes of the participants of the diabetes camp and their propensity score-matched controls who underwent conventional diabetes education (n=93). Results The levels of HbA1c during the first year after the diabetes camp were comparable to those of the matched controls (P=0.341). In an analysis of all participants of the diabetes camp, the 1-year mean±standard deviation (SD) of HbA1c decreased (P=0.010 and P=0.041) after the diabetes camp, whereas the adjusted SD and coefficient of variance (CV) of HbA1c did not decrease. The adjusted SD and CV significantly decreased after the diabetes camp in participants whose 1-year mean HbA1c was ≥6.5% before the diabetes camp (n=40) and those with a duration of diabetes less than 15 years (n=32). Conclusion The 1-year mean and SD of HbA1c decreased after the diabetes camp, with significant reduction in the adjusted SD and CV in those with higher baseline HbA1c and a shorter duration of diabetes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252e87808bec808e620cb91f108feb47Test
https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-99.pdfTest

المؤلفون: Young Min Cho, Jae Hyun Bae, Chang Ho Ahn

المصدر: Diabetes & Metabolism Journal

مصطلحات موضوعية: Adult, Blood Glucose, Dietary Fiber, Male, Endocrinology, Diabetes and Metabolism, Appetite, Satiation, Eating, Young Adult, Glucagon-Like Peptide 1, Diabetes mellitus, Humans, Insulin, Medicine, Peptide YY, Obesity, Food science, Total energy, Meals, Consumption (economics), business.industry, Response, Proteins, A protein, Postprandial Period, medicine.disease, Healthy Volunteers, Healthy individuals, Female, Dietary fiber, Energy Intake, business

الوصف: A premeal load of protein can increase satiety and reduce energy intake. Dietary fiber also conveys metabolic benefits by modulating energy intake. We made a protein-enriched, dietary fiber-fortified bar (PFB) and aimed to investigate its effects on food intake and gut hormone secretion in healthy individuals.Twenty subjects with normal glucose tolerance were enrolled. On three separate visits, the subjects received, in a randomized order, one of the following: a PFB containing 73 kcal with 10.7 g of protein and 12.7 g of dietary fiber; a usual bar (UB) containing the same calories as the PFB but only 0.9 g of protein and no dietary fiber; or water (control). After 15 minutes, the subjects hadTotal energy intake, including the bar and the test meal, was significantly reduced with the PFB preload compared to the water (904.4±534.9 kcal vs. 1,075.0±508.0 kcal,In healthy individuals, a premeal supplementation of PFB reduced total energy intake and decreased postprandial glucose excursion. This finding necessitates long-term studies regarding clinical use in obesity.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7ea044c6255ba0e3dd35de0ed64b48Test
https://doi.org/10.4093/dmj.2020.0026Test

المؤلفون: Seul Gi Yoo, Kyoung Hwa Lee, Kyungdo Han, Yeonju La, Da Eun Kwon, Sang Hoon Han

المصدر: Diabetes & Metabolism Journal

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, endocrine system diseases, Epidemiology, Endocrinology, Diabetes and Metabolism, Population, Cytomegalovirus, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Diabetes mellitus, Republic of Korea, medicine, Humans, Disease, education, Aged, Dyslipidemias, education.field_of_study, Type 1 diabetes, business.industry, Incidence, Incidence (epidemiology), nutritional and metabolic diseases, Type 2 Diabetes Mellitus, Diabetes mellitus, type 2, Odds ratio, Middle Aged, medicine.disease, Case-Control Studies, Cytomegalovirus Infections, Hypertension, Cohort, Kidney Failure, Chronic, Original Article, Female, business, Follow-Up Studies, Cohort study

الوصف: Background: A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated im mune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We evalu ated impact of CMV diseases on new-onset type 2 diabetes mellitus (T2DM). Methods: From the Korean Health Insurance Review and Assessment Service claim database of entire population with 50 mil lion, we retrieved 576 adult case group with CMV diseases diagnosed with International Statistical Classification of Diseases and Related-Health Problems 10th Revision (ICD-10) B25 code between 2010 and 2014 after exclusion of patients with T2DM to 2006. The 2,880 control patients without T2DM from 2006 to cohort entry point were selected between 2010 and 2014 by age, sex matching with case group. The subjects without new-onset T2DM were followed until 2015. T2DM, hypertension (HTN), dyslip idemia (DYS), and end-stage renal disease (ESRD) were coded as ICD-10. Results: The frequency of new-onset T2DM in case group was significantly higher than that in control (5.6% vs. 2.2%, P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba51e48c27de7e2ef76822aec1cd03efTest
https://doi.org/10.4093/dmj.2018.0167Test