Early effects of tumor necrosis factor inhibition on bone homeostasis after soluble tumor necrosis factor receptor use
| العنوان: | Early effects of tumor necrosis factor inhibition on bone homeostasis after soluble tumor necrosis factor receptor use |
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| المؤلفون: | Min Jung Son, Won Park, Shin Goo Park, Seong Ryul Kwon, Mie Jin Lim, Kowoon Joo |
| المصدر: | The Korean Journal of Internal Medicine |
| بيانات النشر: | Korean Association of Internal Medicine, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | musculoskeletal diseases, Adult, Genetic Markers, Male, Arthritis, rheumatoid, medicine.medical_specialty, Time Factors, Bone morphogenetic protein, Vascular endothelial growth inhibitor, Collagen Type I, Receptors, Tumor Necrosis Factor, Etanercept, Bone remodeling, immune system diseases, Internal medicine, medicine, Homeostasis, Humans, skin and connective tissue diseases, Receptor, Adaptor Proteins, Signal Transducing, TNFR-Fc fusion protein, Tumor Necrosis Factor-alpha, business.industry, Middle Aged, Alkaline Phosphatase, medicine.disease, Treatment Outcome, Endocrinology, Immunoglobulin G, Rheumatoid arthritis, Bone Morphogenetic Proteins, Original Article, Female, Tumor necrosis factor alpha, Inflammation Mediators, Peptides, business, Lymphotoxin beta receptor, Biomarkers, Immunosuppressive Agents |
| الوصف: | Background/Aims Our aim was to assess whether short-term treatment with soluble tumor necrosis factor (TNF) receptor affects circulating markers of bone metabolism in rheumatoid arthritis (RA) patients. Methods Thirty-three active RA patients, treated with oral disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids for > 6 months, were administered etanercept for 12 weeks. Serum levels of bone metabolism markers were compared among patients treated with DMARDs at baseline and after etanercept treatment, normal controls and naive RA patients not previously treated with DMARDs (both age- and gender-matched). Results Bone-specific alkaline phosphatase (BSALP) and serum c-telopeptide (CTX)-1 levels were lower in RA patients treated with DMARDs than in DMARD-naive RA patients. After 12 weeks of etanercept treatment, serum CTX-1 and sclerostin levels increased. In patients whose DAS28 improved, the sclerostin level increased from 1.67 ± 2.12 pg/mL at baseline to 2.51 ± 3.03 pg/mL, which was statistically significant (p = 0.021). Increases in sclerostin levels after etanercept treatment were positively correlated with those of serum CTX-1 (r = 0.775), as were those of BSALP (r = 0.755). Conclusions RA patients treated with DMARDs showed depressed bone metabolism compared to naive RA patients. Increases in serum CTX-1 and sclerostin levels after short-term etanercept treatment suggest reconstitution of bone metabolism homeostasis. |
| تدمد: | 2005-6648 1226-3303 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe6441a4ce83cc7b5c768bdc55a8885Test https://doi.org/10.3904/kjim.2014.29.6.807Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....afe6441a4ce83cc7b5c768bdc55a8885 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20056648 12263303 |
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