Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 Levels in Patients with Acute Paraquat Intoxication
| العنوان: | Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 Levels in Patients with Acute Paraquat Intoxication |
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| المؤلفون: | Su-Jin Seok, Jong-Oh Yang, Eun Young Lee, Sae-Yong Hong, Hyo-Wook Gil, Su-Ji Kim |
| المصدر: | Journal of Korean Medical Science |
| بيانات النشر: | Korean Academy of Medical Sciences, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, Paraquat, medicine.medical_specialty, Tissue plasminogen activator, Fibrin Fibrinogen Degradation Products, chemistry.chemical_compound, Risk Factors, Internal medicine, Plasminogen Activator Inhibitor 1, medicine, Humans, Aged, chemistry.chemical_classification, Creatinine, Reactive oxygen species, Univariate analysis, integumentary system, Fibrin degradation product, Herbicides, business.industry, Pharmacology, Drug Therapy & Toxicology, General Medicine, Middle Aged, Endocrinology, Biochemistry, chemistry, Tissue Plasminogen Activator, Plasminogen activator inhibitor-1, Acute Disease, Female, Original Article, Reactive Oxygen Species, Tomography, X-Ray Computed, business, Plasminogen activator, medicine.drug |
| الوصف: | To investigate the effects of reactive oxygen species (ROS) on tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) plasma levels, and their possible implications on clinical outcome, we measured tPA and PAI-1 levels in 101 patients with acute paraquat (PQ) intoxication. The control group consisted of patients who ingested non-PQ pesticides during the same period. tPA and PAI-1 levels were higher in the PQ group than in the controls. PQ levels were significantly correlated with ingested amount, timelag to hospital, tPA level, and hospitalization duration. tPA levels were correlated with PAI-1, fibrin degradation product (FDP), and D-dimer. D-dimer levels were lower in the PQ group than in the controls. Univariate analysis indicated the following significant determinants of death: age, ingested amount, PQ level, timelag to hospital, serum creatinine, lipase, pH, pCO(2), HCO(3) (-), WBC, FDP, PAI-1, and tPA. However, multivariate analysis indicated that only PQ level was significant independent factor predicting death. In conclusion, tPA and PAI-1 levels were higher, while D-dimer levels were lower in the PQ group than in the controls, implying that ROS stimulate tPA and PAI-1, but PAI-1 activity overrides tPA activity in this setting. Decreased fibrinolytic activity appears to be one of the clinical characteristics of acute PQ intoxication. |
| تدمد: | 1598-6357 1011-8934 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641bb1a9e537519cf64c3739cf3e0b62Test https://doi.org/10.3346/jkms.2011.26.4.474Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....641bb1a9e537519cf64c3739cf3e0b62 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15986357 10118934 |
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