دورية أكاديمية
Clinicopathologic Analysis of Proton Pump Inhibitor-Responsive Esophageal Eosinophilia in Korean Patients
| العنوان: | Clinicopathologic Analysis of Proton Pump Inhibitor-Responsive Esophageal Eosinophilia in Korean Patients |
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| المساهمون: | College of Medicine, Dept. of Internal Medicine, Da Hyun Jung, Gak-Won Yun, Yoo Jin Lee, Yunju Jo, Hyojin Park, Park, Hyo Jin, Yun, Gak Won, Jung, Da Hyun |
| بيانات النشر: | Editorial Office of Gut and Liver Korea (South) |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Asian Continental Ancestry Group, Chest Pain/etiology, Deglutition Disorders/etiology, Diagnosis, Differential, Eosinophilic Esophagitis/complications, Eosinophilic Esophagitis/drug therapy, Eosinophilic Esophagitis/pathology, Esophagus/pathology, Female, Follow-Up Studies, Gastroesophageal Reflux/etiology, Heartburn/etiology, Humans, Male, Middle Aged, Pharyngitis/etiology, Phenotype, Proton Pump Inhibitors/therapeutic use, Republic of Korea, Retrospective Studies, Sensation Disorders/etiology, Treatment Outcome, Young Adult, Eosinophilic esophagitis, Proton pump inhibitor responsive esophageal eosinophilia, Proton pump inhibitors |
| الوصف: | BACKGROUND/AIMS: Proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is a newly recognized form of eosinophilic esophagitis (EoE) that responds to PPI therapy. It remains unclear whether PPI-REE represents a subphenotype of gastroesophageal reflux disease, a subphenotype of EoE, or its own distinct entity. The aim was to evaluate the clinicopathologic features of PPI-REE. METHODS: Six patients were diagnosed with PPI-REE based on symptoms, endoscopic abnormalities, esophageal eosinophilia with �돟15 eosinophils/high-power field, and a response to PPI treatment. Symptoms and endoscopic and pathological findings were evaluated. RESULTS: The median follow-up duration was 12 months. Presenting symptoms included dysphagia, heartburn, chest pain, foreign body sensation, acid reflux, and sore throat. All patients had typical endoscopic findings of EoE such as esophageal rings, linear furrows, nodularity, and whitish plaques. Three patients had a concomitant allergic disorder, and one had reflux esophagitis. Four patients exhibited elevated serum IgE, and five had positive skin prick tests. All patients experienced symptomatic resolution within 4 weeks and histologic resolution within 8 weeks after starting PPI therapy. There was no symptomatic recurrence. CONCLUSIONS: PPI therapy induced rapid resolution of symptoms and eosinophil counts in patients with PPI-REE. Large-scale studies with long-term follow-up are warranted. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 37~41 |
| اللغة: | English |
| تدمد: | 1976-2283 2005-1212 25963082 |
| العلاقة: | GUT AND LIVER; J00954; OAK-2016-01354; https://ir.ymlib.yonsei.ac.kr/handle/22282913/146558Test; T201601907; GUT AND LIVER, Vol.10(01) : 37-41, 2016 |
| DOI: | 10.5009/gnl14269 |
| الإتاحة: | https://doi.org/10.5009/gnl14269Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/146558Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.5D196AA8 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19762283 20051212 25963082 |
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| DOI: | 10.5009/gnl14269 |