دورية أكاديمية
Serum Total Homocysteine Level in Association with Folate and Vitamin B12 Status Among Algerian Prostate Cancer Patients
| العنوان: | Serum Total Homocysteine Level in Association with Folate and Vitamin B12 Status Among Algerian Prostate Cancer Patients |
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| المؤلفون: | Mouhoub, Rima, Haddad, Karima, Belhout, Meriem, Chibane, Abdel Aziz, Cherifi, Mohamed El-Hadi, Djerdjouri, Bahia, Khelil, Malika |
| المصدر: | Medical Technologies Journal; Vol. 3 No. 2 (2019): April-June 2019; 420-420 ; 2572-004X ; 10.26415/2572-004X-vol3iss2 |
| بيانات النشر: | Knowledge Kingdom Publishing |
| سنة النشر: | 2019 |
| المجموعة: | Medical Technologies Journal |
| مصطلحات موضوعية: | Prostate cancer, Homocysteine, Vitamin B12, Folate |
| الوصف: | Background: Folate, vitamin B12 and homocysteine are essential for methyl group metabolism and thus also for DNA methylation and metabolic disorders may lead to carcinogenesismetabolic disorders, which may lead to carcinogenesis. In the present study, we proposed to evaluate the associations between folate and vitamin B12, with fasting plasma tHcy concentration in prostate cancer (PCa) patients. Methods: A case –control study was conducted with 40 newly patients with prostate cancer diagnosed with prostate cancer and 50 age matched healthy controls. Serum level of total homocysteine, folate and vitamin B12 were measured by enzyme conversion immunoassay and radioassay, respectively using the ARCHITECT system (both Abbott–Diagnostics Division). Results: The average rate of total PSA was 20.97 ng / ml (ranged between 8- 60 ng / ml). 53% of patients had a PSA≥20ng/ml. Histology confirmed that all patients accounted for prostatic adenocarcinoma with prognostic Gleason score that ranged between 7 and 8 . There are no significant differences between cases and controls about serum Hcy levels (adjusted OR=0.160% CI =0.832-1.031), folate levels (adjusted OR=0.428% CI =0.977-1.008) and vitamin B12 (adjusted OR=0.103% CI =0.992-1.001). Conclusion: In this study, the results show that homocysteine is not involved in prostate cancer. However, this study shows that the sporadic form is much more prevalent than familial one. The diagnosis is often made too late in advanced stage with a high PSA levels and biopsy showing high levels of Gleason |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; application/epub+zip |
| اللغة: | English |
| العلاقة: | https://medtech.ichsmt.org/index.php/MTJ/article/view/227/144Test; https://medtech.ichsmt.org/index.php/MTJ/article/view/227/469Test; https://medtech.ichsmt.org/index.php/MTJ/article/view/227Test |
| DOI: | 10.26415/2572-004X-vol3iss2p420-420 |
| الإتاحة: | https://doi.org/10.26415/2572-004X-vol3iss2p420-420Test https://doi.org/10.26415/2572-004X-vol3iss2Test https://medtech.ichsmt.org/index.php/MTJ/article/view/227Test |
| حقوق: | Copyright (c) 2019 Knowledge Kingdom Publishing |
| رقم الانضمام: | edsbas.C1CA376E |
| قاعدة البيانات: | BASE |
| DOI: | 10.26415/2572-004X-vol3iss2p420-420 |
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