دورية أكاديمية
Follicular lymphoma tregs have a distinct transcription profile impacting their migration and retention in the malignant lymph node
| العنوان: | Follicular lymphoma tregs have a distinct transcription profile impacting their migration and retention in the malignant lymph node |
|---|---|
| المؤلفون: | Nedelkovska, Hristina, Rosenberg, Alexander F., Hilchey, Shannon P., Hyrien, Ollivier, Burack, W. Richard, Quataert, Sally A., Baker, Christina M., Azadniv, Mitra, Welle, Stephen L., Ansell, Stephen M., Kim, Minsoo, Bernstein, Steven H. |
| المصدر: | Biology |
| بيانات النشر: | KnightScholar |
| سنة النشر: | 2016 |
| المجموعة: | SUNY Geneseo KnightScholar (State University of New York) |
| مصطلحات موضوعية: | chemokine receptor CCR7, chemokine receptor CXCR5, CXCL13 chemokine, cytotoxic T lymphocyte antigen 4, glucocorticoid induced tumor necrosis factor receptor, interleukin 10, interleukin 16, L selectin, sphingosine 1 phosphate receptor, transcriptome, tumor protein, Article, B lymphocyte, cellular distribution, clinical article, down regulation, follicular lymphoma, genetic transcription, human, human cell, human tissue, lymph node, lymphocyte migration, malignant lymph node, protein expression, regulatory T lymphocyte, RNA sequence, upregulation, cell motion, female |
| الوصف: | We have previously shown that regulatory T cells (Tregs) infiltrating follicular lymphoma lymph nodes are quantitatively and qualitatively different than those infiltrating normal and reactive nodes. To gain insight into how such Treg populations differ, we performed RNA sequence (RNAseq) analyses on flow sorted Tregs from all three sources. We identify several molecules that could contribute to the observed increased suppressive capacity of follicular lymphoma nodal tregs, including upregulation of CTLA-4, IL-10, and GITR, all confirmed by protein expression. In addition, we identify, and confirm functionally, a novel mechanism by which Tregs target to and accumulate within a human tumor microenvironment, through the down regulation of S1PR1, SELL (L-selectin) and CCR7, potentially resulting in greater lymph node retention. In addition we identify and confirm functionally the upregulation of the chemokine receptor CXCR5 as well as the secretion of the chemokines CXCL13 and IL-16 demonstrating the unique ability of the follicular derived Tregs to localize and accumulate within not only the malignant lymph node, but also localize and accumulate within the malignant B cell follicle itself. Such findings offer significant new insights into how follicular lymphoma nodal Tregs may contribute to the biology of follicular lymphoma and identify several novel therapeutic targets. © 2016 Nedelkovska et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://knightscholar.geneseo.edu/biology/40Test; https://knightscholar.geneseo.edu/context/biology/article/1039/viewcontent/follicularlymphoma.PDFTest |
| الإتاحة: | https://knightscholar.geneseo.edu/biology/40Test https://knightscholar.geneseo.edu/context/biology/article/1039/viewcontent/follicularlymphoma.PDFTest |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.D6527CDE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |