CA19-9 capability as predictor of pancreatic cancer resectability in a Spanish cohort
| العنوان: | CA19-9 capability as predictor of pancreatic cancer resectability in a Spanish cohort |
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| المؤلفون: | Herreros-Villanueva M, Ruiz-Rebollo L, Montes M, Rodriguez-Lopez M, Francisco M, Cubiella J, Iyo E, Garabitos E, Moneo E, Martos M, de Madaria E, Mart?nez-Arranz I, Garc?a-Cougil M, Iglesias-G?mez A, Bujanda L |
| المصدر: | MOLECULAR BIOLOGY REPORTS r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname |
| بيانات النشر: | Kluwer Academic Publishers, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Sensitivity, endocrine system diseases, Specificity, Resectability, Pancreatic cancer, CA19-9, digestive system diseases, Biomarkers |
| الوصف: | CA19-9 serum has been suggested as a marker of unresectability but different cut-off levels have been published. A cut-off of 500 U/ml is currently considered in an international consensus as biological criteria of borderline resectable pancreatic adenocarcinoma. To evaluate whether serum CA19-9 threshold of 500 U/ml could be adequate predictor of resectability in pancreatic adenocarcinoma. Multicenter, observational, prospective study performed in Spain including 203 patients diagnosed with pancreatic adenocarcinoma. 43 (21.2%) cases were resectable and 160 (78.8%) unresectable. Among the 176 preoperative CA19-9 available values, 98 (58.3%) were 500 U/ml. Resectability rate in those patients with CA19-9 500 U/ml. Statistical model to predict resectability based on CA19-9 provide an AUC of 0.6618 (95% CI 0.53-0.83) when only CA19-9 values > 500 U/ml are studied. Serum levels of CA19-9 higher than 500 U/ml are indicative of unresectable disease, however reduced sensitivity and specificity lead to a limited clinical applicability for resectability. |
| تدمد: | 0301-4851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::3e3cf7e0e65537f3e08f0e2fefdcd39cTest https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=5970Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.RECOLECTA.....3e3cf7e0e65537f3e08f0e2fefdcd39c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03014851 |
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