دورية أكاديمية
Whipple’s Disease: A Rare Cause of Malabsorption Syndrome
| العنوان: | Whipple’s Disease: A Rare Cause of Malabsorption Syndrome |
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| المؤلفون: | Joana Cardoso, Lídia Gomes, Sandra Santos, Hélder Moreira, Paula Gomes, João Rua, Jorge Fortuna |
| المصدر: | GE: Portuguese Journal of Gastroenterology, Pp 1-7 (2019) |
| بيانات النشر: | Karger Publishers, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | whipple’s disease, tropheryma whipplei, periodic acid-schiff, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Introduction: Whipple’s disease is a rare, chronic, systemic disease caused by the actinomycete Tropheryma whipplei. Clinical manifestations vary widely depending on the affected system, the most common being the digestive tract. Case Presentation: The authors report the case of a 52-year-old man with malabsorption syndrome, diarrhea, marked weight loss, melanoderma, and visual and proprioception disorders. Periodic acid-Schiff staining of a proximal small bowel biopsy and peripheral-blood PCR identification of T. whipplei confirmed the disease. The patient was initially treated with intravenous ceftriaxone, followed by oral trimethoprim/sulfamethoxazole with significant clinical improvement. Conclusions: This case is reported due to its rarity and the diagnostic challenge it presents. Although uncommon, Whipple’s disease should be considered as a differential diagnosis of malabsorption syndrome due to its systemic impact and possible treatment with targeted antibiotic therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2341-4545 2387-1954 |
| العلاقة: | https://www.karger.com/Article/FullText/504760Test; https://doaj.org/toc/2341-4545Test; https://doaj.org/toc/2387-1954Test |
| DOI: | 10.1159/000504760 |
| الوصول الحر: | https://doaj.org/article/073675fd5a4a48f78e7cf08b5084045dTest |
| رقم الانضمام: | edsdoj.073675fd5a4a48f78e7cf08b5084045d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23414545 23871954 |
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| DOI: | 10.1159/000504760 |