دورية أكاديمية
Urinary Metabolic Profile of Patients with Transfusion-Dependent β-Thalassemia Major Undergoing Deferasirox Therapy
| العنوان: | Urinary Metabolic Profile of Patients with Transfusion-Dependent β-Thalassemia Major Undergoing Deferasirox Therapy |
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| المؤلفون: | Giovanna Capolongo, Miriam Zacchia, Amerigo Beneduci, Silvia Costantini, Patrizia Cinque, Anna Spasiano, Giuseppina De Luca, Maria Enrica Di Pietro, Paolo Ricchi, Francesco Trepiccione, Giovambattista Capasso, Aldo Filosa |
| المصدر: | Kidney & Blood Pressure Research, Vol 45, Iss 3, Pp 455-466 (2020) |
| بيانات النشر: | Karger Publishers, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Dermatology LCC:Diseases of the circulatory (Cardiovascular) system LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | β-thalassemia major, metabolomics, urinomics, tubular function, renal disease, Dermatology, RL1-803, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Introduction: Renal dysfunction is a frequent complication in patients suffering from β-thalassemia major (β-TM). The aim of this study was to analyze the renal function and urine metabolomic profile of β-TM patients undergoing transfusions and deferasirox (DFX) therapy, in order to better characterize and shed light on the pathogenesis of renal disease in this setting. Methods and Subjects: 40 patients affected by β-TM treated with DFX and 35 age- and gender-matched healthy controls were enrolled in the study. Renal function was assessed. Glomerular filtration rate (GFR) was estimated with CKD-EPI and Schwartz formula for adults and children, respectively. Renal tubular function and maximal urine concentration ability were tested. Urine specimens were analyzed by nuclear magnetic resonance spectroscopy to identify the urinary metabolite profiles. Results: The study of renal function in β-TM patients revealed normal estimated (e)GFR mean values and the albumin-to-creatinine ratio was |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1420-4096 1423-0143 |
| العلاقة: | https://www.karger.com/Article/FullText/507369Test; https://doaj.org/toc/1420-4096Test; https://doaj.org/toc/1423-0143Test |
| DOI: | 10.1159/000507369 |
| الوصول الحر: | https://doaj.org/article/e03381b68a9c4e788fc4ab009c5ff0dbTest |
| رقم الانضمام: | edsdoj.03381b68a9c4e788fc4ab009c5ff0db |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 14204096 14230143 |
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| DOI: | 10.1159/000507369 |