دورية أكاديمية
Relations of Visceral and Abdominal Subcutaneous Adipose Tissue, Body Mass Index, and Waist Circumference to Serum Concentrations of Parameters of Chronic Inflammation
| العنوان: | Relations of Visceral and Abdominal Subcutaneous Adipose Tissue, Body Mass Index, and Waist Circumference to Serum Concentrations of Parameters of Chronic Inflammation |
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| المؤلفون: | Inga Schlecht, Beate Fischer, Gundula Behrens, Michael F. Leitzmann |
| المصدر: | Obesity Facts, Vol 9, Iss 3, Pp 144-157 (2016) |
| بيانات النشر: | Karger Publishers, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Nutritional diseases. Deficiency diseases |
| مصطلحات موضوعية: | Chronic inflammation, Visceral adipose tissue, Subcutaneous adipose tissue, Ultrasonography, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Background: Different measures of body fat composition may vary in their relations to parameters of chronic inflammation. Methods: We assessed the relations of visceral (VAT) and subcutaneous adipose tissue (SAT), BMI, and waist circumference (WC) to serum concentrations of high-sensitive C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), resistin, and adiponectin in 97 healthy adults using multivariate linear regression models, adjusted for age, sex, smoking, physical activity, menopausal status, and use of aspirin or non-steroidal anti-inflammatory drugs (NSAIDs). Parameters of chronic inflammation were mutually adjusted. Results: VAT (β = 0.34), SAT (β = 0.43), BMI (β = 0.40), and WC (β = 0.47) were all significantly associated with hs-CRP. BMI was additionally inversely related to adiponectin (β = -0.29). In exploratory subgroup analyses defined by gender, BMI, smoking, and use of aspirin or NSAIDs, VAT was the strongest indicator for increased levels of IL-6, SAT was the most consistent indicator for increased levels of hs-CRP, and BMI was the most consistent indicator for decreased levels of adiponectin. WC showed to be a weak indicator for increased levels of hs-CRP and decreased levels of adiponectin. Conclusion: VAT, SAT, BMI, and WC show distinct associations with parameters of chronic inflammation. Whether these differences reflect differential metabolic risks requires clarification by longitudinal studies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1662-4025 1662-4033 00044369 |
| العلاقة: | http://www.karger.com/Article/FullText/443691Test; https://doaj.org/toc/1662-4025Test; https://doaj.org/toc/1662-4033Test |
| DOI: | 10.1159/000443691 |
| الوصول الحر: | https://doaj.org/article/27593493fb8043b58223f0bce8da965bTest |
| رقم الانضمام: | edsdoj.27593493fb8043b58223f0bce8da965b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16624025 16624033 00044369 |
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| DOI: | 10.1159/000443691 |