Central Obesity, C-Reactive Protein and Chronic Kidney Disease: A Community-Based Cross-Sectional Study in Southern China
| العنوان: | Central Obesity, C-Reactive Protein and Chronic Kidney Disease: A Community-Based Cross-Sectional Study in Southern China |
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| المؤلفون: | Yongqiang Li, Hongmei Liu, Yan Liang, Harry Holthöfer, Xiaofei Shao, Xinyu Liu, Hequn Zou, Mi Li, Shanying Chen |
| المصدر: | Kidney & Blood Pressure Research, Vol 37, Iss 4-5, Pp 392-401 (2013) |
| بيانات النشر: | Karger Publishers, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, China, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Waist, Cross-sectional study, Logistic regression, lcsh:RC870-923, Residence Characteristics, Risk Factors, Internal medicine, Chronic kidney disease, medicine, lcsh:Dermatology, Humans, Obesity, Renal Insufficiency, Chronic, Aged, Inflammation, biology, business.industry, C-reactive protein, General Medicine, Middle Aged, lcsh:RL1-803, medicine.disease, lcsh:Diseases of the genitourinary system. Urology, C-Reactive Protein, Cross-Sectional Studies, Endocrinology, Nephrology, lcsh:RC666-701, Obesity, Abdominal, biology.protein, Female, Waist Circumference, Metabolic syndrome, Cardiology and Cardiovascular Medicine, business, Body mass index, Biomarkers, Kidney disease |
| الوصف: | Objective: Previous studies have shown that central obesity is associated with chronic kidney disease (CKD). We hypothesized that the association of central obesity with CKD is modified by the presence of inflammation. To test this hypothesis, we performed this study. Methods: This was a cross-sectional study in southern China. Waist-to-height ratio (WHtR) was used as a central obesity index and C-reactive protein (CRP) was used as an index for inflammation. CKD was defined as estimated glomerular filtration rate(eGFR) 2 or albuminuria-to-creatinine ratio (ACR) >30mg/g. Multivariable logistic regressions were used and logistic regression models were adjusted for potential confounders and other components of metabolic syndrome. Results: 1834 subjects were included in the current study. WHtR, body mass index and waist circumference were significantly associated with the level of CRP. When adjustment for potential confounders, only central obesity with a higher CRP level was associated with CKD (Relavitve-risk Ratio, 95% CI: 1.68, 1.03 - 2.75, P = 0.04). In multivariate logistic models, WHtR was associated with CKD. The odd ratio for WHtR (every SD increment), was 1.38 (95% CI 1.15, 1.66, P < 0.001). Further adjustment for log-transformed CRP had an impact on the odd ratios. Conclusion: Central obesity is associated with CKD, independently of other MetS components. Central obesity is also associated with inflammation and the presence of inflammation modifies the associations of central obesity and CKD. This study is based on a community-based chinese population, and the results may only be applicable for Chinese population. |
| اللغة: | English |
| تدمد: | 1423-0143 1420-4096 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d79eccb3197275e90f0adeb64fc2c39Test http://www.karger.com/Article/FullText/355718Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7d79eccb3197275e90f0adeb64fc2c39 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230143 14204096 |
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