التفاصيل البيبلوغرافية
| العنوان: |
Tissue-Specific Utilization of Menaquinone-4 Results in the Prevention of Arterial Calcification in Warfarin-Treated Rats. |
| المؤلفون: |
Spronk, H.M.H.1 henri.spronk@bioch.unimaas.nl, Soute, B.A.M.2, Schurgers, L.J.2, Thijssen, H.H.W.3, De Mey, J.G.R.3, Vermeer, C.2 |
| المصدر: |
Journal of Vascular Research. 2003, Vol. 40 Issue 6, p531-537. 7p. 1 Color Photograph, 2 Charts. |
| مصطلحات موضوعية: |
*ARTERIAL calcification, *ARTERIES, *ANTICOAGULANTS, *ATHEROSCLEROSIS, *EXTRACELLULAR matrix, *VITAMIN K |
| مستخلص: |
The effects of vitamin K (phylloquinone: K1 and menaquinone-4: MK-4) on vascular calcification and their utilization in the arterial vessel wall were compared in the warfarin-treated rat model for arterial calcification. Warfarin-treated rats were fed diets containing K1, MK-4, or both. Both K1 and MK-4 are cofactors for the endoplasmic reticulum enzyme γ-glutamyl carboxylase but have a structurally different aliphatic side chain. Despite their similar in vitro cofactor activity we show that MK-4 and not K1 inhibits warfarin-induced arterial calcification. The total hepatic K1 accumulation was threefold higher than that of MK-4, whereas aortic MK-4 was three times that of K1. The utilization of K1 and MK-4 in various tissues was estimated by calculating the ratios between accumulated quinone and epoxide species. K1 and MK-4 were both equally utilized in the liver, but the aorta showed a more efficient utilization of MK-4. Therefore, the observed differences between K1 and MK-4 with respect to inhibition of arterial calcification may be explained by both differences in their tissue bioavailability and cofactor utilization in the reductase/carboxylase reaction. An alternative explanation may come from an as yet hypothetical function of the geranylgeranyl side chain of MK-4, which is a structural analogue of geranylgeranyl pyrophosphate and could interfere with a critical step in the mevalonate pathway. Copyright © 2003 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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