التفاصيل البيبلوغرافية
| العنوان: |
Impact of Diet and/or Exercise Intervention on Infrapatellar Fat Pad Morphology: Secondary Analysis from the Intensive Diet and Exercise for Arthritis (IDEA) Trial. |
| المؤلفون: |
Pogacnik Murillo, aarón Leonardo, Eckstein, Felix, Wirth, Wolfgang, Beavers, Daniel, Loeser, Richard F., Nicklas, Barbara J., Mihalko, Shannon L., Miller, Gary D., Hunter, David J., Messier, Stephen P. |
| المصدر: |
Cells Tissues Organs; Apr2017, Vol. 203 Issue 4, p258-266, 9p, 1 Diagram, 4 Charts, 1 Graph |
| مصطلحات موضوعية: |
ADIPOSE tissues, CYTOKINES, OSTEOARTHRITIS, RADIOGRAPHY, MAGNETIC resonance |
| مستخلص: |
Objectives: The infrapatellar fat pad (IPFP) represents intraarticular adipose tissue that may contribute to intra-articular inflammation and pain by secretion of proinflammatory cytokines. Here we examined the impact of weight loss by diet and/or exercise interventions on the IPFP volume. Methods: Intensive Diet and Exercise for Arthritis (IDEA) was a single-blinded, single-center, 18-month, prospective, randomized controlled trial that enrolled 454 overweight and obese older adults with knee pain and radiographic osteoarthritis. Participants were randomized to 1 of 3 groups: exercise-only control (E), diet-induced weight loss (D), and diet-induced weight loss + exercise (D+E). In a subsample (n = 106; E: n = 36, D: n = 35, and D+E: n = 35), magnetic resonance images were acquired at baseline and at the 18-month follow-up, from which we analyzed IPFP volume, surface areas, and thickness in this secondary analysis. Results: The average weight loss amounted to 1.0% in the E group, 10.5% in the Dgroup, and 13.0% in the D+E group. A significant (p < 0.01) reduction in IPFP volume was observed in the E (2.1%), D (4.0%), and D+E (5.2%) groups. The IPFP volume loss in the D+E group was significantly greater than that in the E group (p < 0.05) when not adjusting for parallel comparisons. Across intervention groups, there were significant correlations between IPFP volume change, individual weight loss (r = 0.40), and change in total body fat mass (dual-energy X-ray absorptiometry; r = 0.44, n = 88) and in subcutaneous thigh fat area (computed tomography; r = 0.32, n = 82). Conclusions: As a potential link between obesity and knee osteoarthritis, the IPFP was sensitive to intervention by diet and/or exercise, and its reduction was correlated with changes in weight and body fat. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
