المؤلفون: Lehle, Karla, Schreml, Stephan, Kunz-Schughart, Leoni A., Rupprecht, Leopold, Birnbaum, Dietrich E., Schmid, Christof, Preuner, Jürgen G.

المصدر: J Vasc Res 2008;45:333–342, ISSN: 1018-1172

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, ddc:610, Adhäsionsmoleküle, Calcineurin-Inhibitoren, mTOR-Inhibitoren, E-Selektin, ICAM-1, VCAM-1, Adhesion molecules, Calcineurin inhibitors, mTOR inhibitors, E-selectin, ICAM-1, VCAM-1

الوصف: We examined the effect of cyclosporin A, tacrolimus, sirolimus and everolimus on the cell growth, viability, proliferation, expression of cellular adhesion molecules (CAM) and leukocyte (PBMC) binding of human macrovascular (coronary artery, saphenous vein) and microvascular endothelial cells (EC). Tacrolimus did not affect EC integrity, growth or expression of CAM. Exclusively, EC from the coronary arteries showed a reduced cellular growth (about 30%) under cyclosporin A and tacrolimus treatment. In contrast, treatment with mTOR inhibitors reduced EC proliferative activity by about 40%, independently of the EC origin. No induction of apoptosis (caspase-3/7 activity) or cytotoxicity (MTS test) was observed. Long-term treatment with high concentrations of sirolimus and everolimus did not enhance the expression of CAM. Stimulation with tumor necrosis factor significantly increased the expression of CAM, independently of the drugs used. None of the mTOR inhibitors influenced the tumor necrosis factor-induced expression of CAM, whereas adhesion of PBMC increased significantly, as described by other papers. In summary, neither calcineurin inhibitors nor mTOR inhibitors activate human micro- and macrovascular EC. Therefore, the investigated drugs are unlikely to contribute to EC activation during transplant-associated vasculopathy.
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.

الإتاحة: https://tud.qucosa.de/id/qucosa%3A27646Test
https://tud.qucosa.de/api/qucosa%3A27646/attachment/ATT-0Test/

المؤلفون: Schreml, Stephan, Hoffmann, Sebastian, Berneburg, Mark

مصطلحات موضوعية: 610 Medizin, ddc:610

الوصف: Bullous pemphigoid (BP) is a blistering autoimmune disease mainly observed in elderly patients. Several triggers are known for this autoimmune disease and some drugs are known to be a cause of BP. However, there are only few case reports on the induction of BP under adalimumab therapy. Other autoimmune diseases, such as lupus erythematosus, are also known to occur under TNF inhibition. Here, we report on an 81-year-old patient who received adalimumab for ulcerative colitis and subsequently developed BP. Other causes of BP (tumors, other drugs, viral or toxoplasma infections) were excluded. We initiated a topical and systemic therapy (prednisolone 1 mg/kg/day) and stopped the adalimumab injections. The patient’s symptoms resolved quickly and we were able to taper corticosteroid therapy. This rare case highlights the importance to monitor for autoimmune events during TNF inhibition.

وصف الملف: application/pdf

العلاقة: https://epub.uni-regensburg.de/37433/1/document.pdfTest; https://epub.uni-regensburg.de/37433/7/1034%29%20image2018-06-28-103150.pdfTest; Schreml, Stephan, Hoffmann, Sebastian und Berneburg, Mark (2018) Bullous Pemphigoid Associated with Adalimumab Therapy in a Patient with Ulcerative Colitis. Case Reports in Dermatology 10, S. 145-148.

الإتاحة: https://doi.org/10.1159/000489163Test
https://epub.uni-regensburg.de/37433Test/
https://epub.uni-regensburg.de/37433/1/document.pdfTest
https://epub.uni-regensburg.de/37433/7/1034%29%20image2018-06-28-103150.pdfTest
https://wwwTest.karger.com/Article/FullText/489163

المؤلفون: Schucht, Kathrin, Schröder, Josef, Siegmund, Heiko, Grafe, Claudia, Schreml, Stephan

مصطلحات موضوعية: 610 Medizin, ddc:610

الوصف: A 52-year-old woman presented with a large partially yellow and erythematous tumor on her right temple. She reported that it had grown over the last 4 years. Regional lymph nodes were impalpable. A punch biopsy showed eosinophilic material in the dermis and subcutis. Immunohistochemistry showed positive staining for kappa and lambda light chains. Electron microscopy showed the typical amyloid fibrils (7–10 nm in diameter). There was no evidence of systemic amyloidosis, paraproteinemia or underlying plasmacytoma. The tumor was completely removed via curettage. At follow-up, the patient presented in good health with no signs of relapse.

وصف الملف: application/pdf

العلاقة: https://epub.uni-regensburg.de/35179/1/447234.pdfTest; Schucht, Kathrin, Schröder, Josef, Siegmund, Heiko, Grafe, Claudia und Schreml, Stephan (2016) Nodular Cutaneous Amyloidosis at the Temple. Case Reports in Dermatology 2016 (8), S. 193-196.

الإتاحة: https://epub.uni-regensburg.de/35179Test/
https://epub.uni-regensburg.de/35179/1/447234.pdfTest
http://wwwTest.karger.com/Article/FullText/447234

المؤلفون: Behm, Barbara, Kemper, Michael, Babilas, Philipp, Abels, Christoph, Schreml, Stephan

مصطلحات موضوعية: 610 Medizin, ddc:610

الوصف: The skin pH is crucial for physiological skin functions. A decline in stratum corneum acidity, as observed in aged or diseased skin, may negatively affect physiological skin functions. Therefore, glycolic acid-containing water-in-oil (W/O) emulsions adjusted to pH 4 were investigated regarding their effect on normal or increased skin pH. A pH 4 W/O emulsion was applied on three areas with pathologically increased skin surface pH in diabetics (n = 10). Further, a 28-day half-side trial (n = 30) was performed to test the long-term efficacy and safety of a pH 4 W/O emulsion (n = 30). In summary, the application of a pH 4 W/O emulsion reduced the skin pH in healthy, elderly and diabetic subjects, which may improve epidermal barrier functions.

وصف الملف: application/pdf

العلاقة: https://epub.uni-regensburg.de/37652/1/17.pdfTest; Behm, Barbara, Kemper, Michael, Babilas, Philipp, Abels, Christoph und Schreml, Stephan (2015) Impact of a Glycolic Acid-Containing pH 4 Water-in-Oil Emulsion on Skin pH. Skin Pharmacology and Physiology 28 (6), S. 290-295.

الإتاحة: https://epub.uni-regensburg.de/37652Test/
https://epub.uni-regensburg.de/37652/1/17.pdfTest
https://wwwTest.karger.com/Article/FullText/439030

المؤلفون: Schreml, Stephan, Meier, Robert Johannes, Albert, M. G., Seidl, U., Zeller, V., Behm, B., Landthaler, Michael, Abels, C., Babilas, Philipp

مصطلحات موضوعية: 540 Chemie, ddc:540, 610 Medizin, ddc:610

الوصف: Background/Aims: The effects of a 10% α-hydroxy acid (AHA) oil/water (O/W) emulsion on the pH of human skin surface (pHss) and stratum corneum (SC; pHsc) were evaluated in vivo. Methods: The AHA O/W emulsion was applied to an area on the volar forearm of male volunteers (n = 12), and then wiped off after 10 min. Prior to application and over the following 3 h, the pHss was measured. We used glass electrode measurements and time domain dual lifetime referencing (tdDLR) with luminescent sensor foils. In another experiment (n = 5), the impact of the AHA O/W emulsion on the pHsc gradient was measured by tape stripping of the SC of the volar forearm after application of the AHA O/W emulsion. Results: Compared with pHss values prior to treatment [5.2 ± 1.7 (tdDLR) or 4.8 ± 0.5 (electrode)], the pHss was significantly reduced 10 min after application [4.0 ± 0.3 (tdDLR) or 4.1 ± 0.1 (electrode)] and the pHss remained significantly reduced over the measurement period of 3 h [after 3 h: 4.4 ± 0.2 (tdDLR) or 4.5 ± 0.3 (electrode)]. The AHA O/W emulsion significantly reduced the pHsc even down to deep layers of the SC. Conclusion: After a 10-min application time, the 10% AHA O/W emulsion reduces the pHss (for at least 3 h) and pHsc in deep layers of the SC.

وصف الملف: application/pdf

العلاقة: https://epub.uni-regensburg.de/40899/1/331204.pdfTest; Schreml, Stephan, Meier, Robert Johannes, Albert, M. G., Seidl, U., Zeller, V., Behm, B., Landthaler, Michael, Abels, C. und Babilas, Philipp (2012) The Impact of 10% α-Hydroxy Acid Emulsion on Skin pH. Skin Pharmacology and Physiology 25, S. 34-38.

الإتاحة: https://epub.uni-regensburg.de/40899Test/
https://epub.uni-regensburg.de/40899/1/331204.pdfTest

المؤلفون: Sander, Dorothea, Schroeder, Josef, Schoenbuchner, Ines, Schreml, Julia, Karrer, Sigrid, Berneburg, Mark, Schreml, Stephan

مصطلحات موضوعية: ddc:no

الوصف: A 50-year-old man presented with congenital scaling and hyperkeratosis on his palms, the soles of his feet and the extensor areas of his joints. The flexural areas were unaffected. His maternal grandmother, questionably his maternal uncle, his mother, all three brothers, one of his two sisters as well as two nephews and three nieces have or had similar skin changes. A punch biopsy was taken from the left palm. Clinical and histological signs led to the diagnosis of erythrodermia congenitalis ichthyosiformis bullosa of Brocq. We confirmed this genetically and found a heterozygous duplication (c.1752dupT) in the keratin 1 gene (KRT-1). To our knowledge, this is the first case of this skin condition reported in the literature with a heterozygous duplication (c.1752dupT) in KRT-1. (C) 2016 The Author(s) Published by S. Karger AG, Basel

العلاقة: Sander, Dorothea, Schroeder, Josef, Schoenbuchner, Ines, Schreml, Julia, Karrer, Sigrid, Berneburg, Mark and Schreml, Stephan orcid:0000-0002-2820-1942 (2016). Erythrodermia Congenitalis Ichthyosiformis Bullosa of Brocq. Case Rep. Dermatol., 8 (1). S. 19 - 22. BASEL: KARGER. ISSN 1662-6567

الإتاحة: https://kups.ub.uni-koeln.de/28935Test/