ERAP1 and PDE8A Are Downregulated in Cattle Protected against Bovine Tuberculosis
| العنوان: | ERAP1 and PDE8A Are Downregulated in Cattle Protected against Bovine Tuberculosis |
|---|---|
| المؤلفون: | Blanco, Federico Carlos, Soria, Marcelo Abel, Klepp, Laura Ines, Bigi, Fabiana |
| المصدر: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| بيانات النشر: | Karger, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | purl.org/becyt/ford/1 [https], Ciencias Biológicas, IMMUNE RESPONSE, Otras Ciencias Biológicas, CATTLE, TRANSCRIPTOMICS, purl.org/becyt/ford/1.6 [https], MYCOBACTERIUM BOVIS, CIENCIAS NATURALES Y EXACTAS |
| الوصف: | Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB. Fil: Blanco, Federico Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina Fil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía; Argentina Fil: Klepp, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina Fil: Bigi, Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::da0ea0f3ec735b5a77ab50087c3eb689Test https://www.karger.com/Article/FullText/479183Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..da0ea0f3ec735b5a77ab50087c3eb689 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |