التفاصيل البيبلوغرافية
| العنوان: |
Hypoxia-Inducible Factor in Thyroid Carcinoma |
| المؤلفون: |
Natalie Burrows, Muhammad Babur, Julia Resch, Kaye J. Williams, Georg Brabant |
| بيانات النشر: |
Journal of Thyroid Research |
| سنة النشر: |
2011 |
| المجموعة: |
Hindawi Publishing Corporation |
| الوصف: |
Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy. In addition to hypoxia, HIF-1 can be activated by growth factor-signalling pathways such as the mitogen-activated protein kinases- (MAPK-) and phosphatidylinositol-3-OH kinases- (PI3K-) signalling cascades. Mutations in these pathways are common in thyroid carcinoma and lead to enhanced HIF-1 expression and activity. Here, we summarise current data that highlights the potential role of both hypoxia and MAPK/PI3K-induced HIF-1 signalling in thyroid carcinoma progression, metastatic characteristics, and the potential role of HIF-1 in thyroid carcinoma response to radiotherapy. Direct or indirect targeting of HIF-1 using an MAPK or PI3K inhibitor in combination with radiotherapy may be a new potential therapeutic target to improve the therapeutic response of thyroid carcinoma to radiotherapy and reduce metastatic burden. |
| نوع الوثيقة: |
review |
| اللغة: |
English |
| العلاقة: |
https://doi.org/10.4061/2011/762905Test |
| DOI: |
10.4061/2011/762905 |
| الإتاحة: |
https://doi.org/10.4061/2011/762905Test |
| حقوق: |
Copyright © 2011 Natalie Burrows et al. |
| رقم الانضمام: |
edsbas.B7C4D71F |
| قاعدة البيانات: |
BASE |
