Comparison of Microbial Diversity and Composition in Jejunum and Colon of the Alcohol-dependent Rats
| العنوان: | Comparison of Microbial Diversity and Composition in Jejunum and Colon of the Alcohol-dependent Rats |
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| المؤلفون: | Ma Meng-Yu, Sun Ya-lun, Yang Fan, Zhao Ya-E, Lu Yu-fan, Zhang Ying, Wei Ji-dong, Zhang Ruiling |
| المصدر: | Journal of Microbiology and Biotechnology. 28:1883-1895 |
| بيانات النشر: | Journal of Microbiology and Biotechnology, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Colon, Alcohol abuse, Alcohol, Gut flora, digestive system, Applied Microbiology and Biotechnology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, RNA, Ribosomal, 16S, Internal medicine, medicine, Animals, Rats, Wistar, Ethanol, Bacteria, biology, Alcohol dependence, Bacteroidetes, Biodiversity, General Medicine, medicine.disease, biology.organism_classification, Gastrointestinal Microbiome, Rats, Alcoholism, Disease Models, Animal, Jejunum, 030104 developmental biology, Endocrinology, chemistry, Dysbiosis, Metagenomics, Metabolic Networks and Pathways, 030217 neurology & neurosurgery, Biotechnology, Ruminococcaceae |
| الوصف: | Alcohol dependence is a global public health problem, yet the mechanisms of alcohol dependence are incompletely understood. The traditional view has been that ethanol alters various neurotransmitters and their receptors in the brain and causes the addiction. However, an increasing amount of experimental evidence suggests that gut microbiota also influence brain functions via gut-to-brain interactions, and may therefore induce the development of alcohol use disorders. In this study, a rat model of alcohol dependence and withdrawal was employed, the gut microbiota composition was analyzed by high-throughput 16S rRNA gene sequencing, and the metagenome function was predicted by PICRUSt software. The results suggested that chronic alcohol consumption did not significantly alter the diversity and richness of gut microbiota in the jejunum and colon, but rather markedly changed the microbiota composition structure in the colon. The phyla Bacteroidetes and eight genera including Bacteroidales S24-7, Ruminococcaceae, Parabacteroides, Butyricimonas, et al were drastically increased, however the genus Lactobacillus and gauvreauii in the colon were significantly decreased in the alcohol dependence group compared with the withdrawal and control groups. The microbial functional prediction analysis revealed that the proportions of amino acid metabolism, polyketide sugar unit biosynthesis and peroxisome were significantly increased in the AD group. This study demonstrated that chronic alcohol consumption has a dramatic effect on the microbiota composition structure in the colon but few effects on the jejunum. Inducement of colonic microbiota dysbiosis due to alcohol abuse seems to be a factor of alcohol dependence, which suggests that modulating colonic microbiota composition might be a potentially new target for treating alcohol addiction. |
| تدمد: | 1738-8872 1017-7825 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5383083a057446a9e4d3d07b49e9f3Test https://doi.org/10.4014/jmb.1806.06050Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8d5383083a057446a9e4d3d07b49e9f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17388872 10177825 |
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